Staying well after depression: trial design and protocol

详细信息    查看全文

• 作者：J Mark G Williams (1)
  Ian T Russell (2) (3)
  Catherine Crane (1)
  Daphne Russell (3)
  Chris J Whitaker (3)
  Danielle S Duggan (1)
  Thorsten Barnhofer (1)
  Melanie JV Fennell (1)
  Rebecca Crane (4)
  Sarah Silverton (4)
  
• 刊名：BMC Psychiatry
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：10
• 期：1
• 全文大小：833KB
• 参考文献：1. Beautrais AL, Joyce PR, Mulder RT, Fergusson DM, Deavoll BJ, Nightingale SK: Prevalence and comorbidity of mental disorders in persons making serious suicide attempts: a case-control study. / Am J Psychiatry 1996,153(8):1009鈥?014.
  2. Williams JMG, Crane C, Barnhofer T, Does AJW, Segal ZV: Recurrence of suicidal ideation across depressive episodes. / Journal of Affective Disorders 2006,91(2鈥?):189鈥?94. CrossRef
  3. Townsend E, Hawton K, Altman DG, Arensman E, Gunnell D, Hazell P, House A, Van Heeringen K: The efficacy of problem-solving treatments after deliberate self-harm: meta-analysis of randomized controlled trials with respect to depression, hopelessness and improvement in problems. / Psychol Med 2001,31(6):979鈥?88. CrossRef
  4. Segal ZV, Williams JMG, Teasdale JD: / Mindfulness-based cognitive therapy for depression: A new approach to preventing relapse. New York, NY,: Guilford Press; 2002.
  5. Ma SH, Teasdale JD: Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. / J Consult Clin Psychol 2004,72(1):31鈥?0. CrossRef
  6. Teasdale JD, Segal ZV, Williams JM, Ridgeway VA, Soulsby JM, Lau MA: Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. / J Consult Clin Psychol 2000,68(4):615鈥?23. CrossRef
  7. Williams JMG, Alatiq Y, Crane C, Barnhofer T, Fennell MJV, Duggan DS, Hepburn S, Goodwin GM: Mindfulness-based Cognitive Therapy (MBCT) in bipolar disorder: Preliminary evaluation of immediate effects on between-episode functioning. / Journal of Affective Disorders 2008,107(1鈥?):275鈥?79. CrossRef
  8. Barnhofer T, Duggan D, Crane C, Hepburn S, Fennell MJV, Williams JMG: Effects of meditation on frontal alpha-asymmetry in previously suicidal individuals. / Neuroreport 2007,18(7):709鈥?12. CrossRef
  9. Crane C, Barnhofer T, Duggan DS, Hepburn S, Fennell MV, Williams JMG: Mindfulness-Based Cognitive Therapy and self-discrepancy in recovered depressed patients with a history of depression and suicidality. / Cognitive Therapy and Research 2008,32(6):775鈥?87. CrossRef
  10. Williams JMG, Barnhofer T, Crane C, Beck AT: Problem solving deteriorates following mood challenge in formerly depressed patients with a history of suicidal ideation. / Journal of Abnormal Psychology 2005,114(3):421鈥?31. CrossRef
  11. Bockting CLH, Schene AH, Spinhoven P, Koeter MWJ, Wouters LF, Huyser J, Kamphuis JH, Grp DS: Preventing relapse/recurrence in recurrent depression with cognitive therapy: A randomized controlled trial. / Journal of Consulting and Clinical Psychology 2005,73(4):647鈥?57. CrossRef
  12. Williams JMG, Russell I, Russell D: Mindfulness-based cognitive therapy: Further issues in current evidence and future research. / Journal of Consulting and Clinical Psychology 2008,76(3):524鈥?29. CrossRef
  13. Murphy E: Social origins of depression in old-age. / Br J Psychiatry 1982,141(AUG):135鈥?42. CrossRef
  14. Sheline YI, Price JL, Vaishnavi SN, Mintun MA, Barch DM, Epstein AA, Wilkins CH, Snyder AZ, Couture L: Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors. / Am J Psychiatry 2008,165(4):524鈥?32. CrossRef
  15. DSMIV-TR: / Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision. Washinton DC: American Psychiatric Association; 1994.
  16. Spitzer RL, Williams JBW, Gibbon M, First MB: The Structured Clinical Interview for DSM-III-R (SCID) .1. history, rationale, and description. / Arch Gen Psychiatry 1992,49(8):624鈥?29.
  17. Linehan MM, Comtois KA, Brown MZ, Heard HL, Wagner A: Suicide Attempt Self-Injury Interview (SASII): Development, reliability, and validity of a scale to assess suicide attempts and intentional self-injury. / Psychological Assessment 2006,18(3):303鈥?12. CrossRef
  18. Bedford A: Manual of the Leeds Scales for the Self-Assessment of Anxiety and Depression - Snaith, RP, Bridge, GWK, Hamilton, M. / British Journal of Social and Clinical Psychology 1979,18(NOV):445鈥?45.
  19. Beck AT, Kovacs M, Weissman A: Assessment of suicidal intention: The Scale for Suicide Ideation. / Journal of Consulting and Clinical Psychology 1979,47(2):343鈥?52. CrossRef
  20. Beck AT, Brown GK, Steer RA: Psychometric characteristics of the Scale for Suicide Ideation with psychiatric outpatients. / Behav Res Ther 1997,35(11):1039鈥?046. CrossRef
  21. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. / J Clin Psychiatry 1998,59(Suppl 20):22鈥?3. quiz 34鈥?7
  22. Beck AT, Ward C, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. / Archives of General Psychiatry 1961, 4:561鈥?71.
  23. Beck AT, Weissman A, Lester D, Trexler L: The measurement of pessimism: the hopelessness scale. / J Consult Clin Psychol 1974,42(6):861鈥?65. CrossRef
  24. Brugha TS, Conroy R: Categories of depression: reported life events in a controlled design. / Br J Psychiatry 1985, 147:641鈥?46. CrossRef
  25. Evans C, Connell J, Barkham M, Margison F, McGrath G, Mellor-Clark J, Audin K: Towards a standardised brief outcome measure: psychometric properties and utility of the CORE-OM. / Br J Psychiatry 2002, 180:51鈥?0. CrossRef
  26. Kind P: The use and usefulness of EQ-5D: Results of an international survey. / Quality of Life Research 1997,6(5):42鈥?2.
  27. Bernstein DP, Fink L, Handelsman L, Foote J, Lovejoy M, Wenzel K, Sapareto E, Ruggiero J: Initial reliability and validity of a new retrospective measure of child-abuse and neglect. In / 146th Annual Meeting of the American-Psychiatric-Association: May 22鈥?7 1993; San Francisco, Ca. Amer Psychiatric Association; 1993:1132鈥?136.
  28. Spitzer RL, Kroenke K, Williams JBW, Lowe B: A brief measure for assessing generalized anxiety disorder - The GAD-7. / Archives of Internal Medicine 2006,166(10):1092鈥?097. CrossRef
  29. Kroenke K, Spitzer RL, Williams JBW: The PHQ-9 - Validity of a brief depression severity measure. / Journal of General Internal Medicine 2001,16(9):606鈥?13. CrossRef
  30. Williams JMG, Broadbent K: Autobiographical memory in suicide attempters. / Journal of Abnormal Psychology 1986,95(2):144鈥?49. CrossRef
  31. Dalgleish T, Williams JMG, Golden AMJ, Perkins N, Barrett LF, Barnard PJ, Yeung CA, Murphy V, Elward R, Tchanturia K, / et al.: Reduced specificity of autobiographical memory and depression: The role of executive control. / Journal of Experimental Psychology-General 2007,136(1):23鈥?2. CrossRef
  32. Baddeley A, DellaSala S, Papagno C, Spinnler H: Dual-task performance in dysexecutive and nondysexecutive patients with a frontal lesion. / Neuropsychology 1997,11(2):187鈥?94. CrossRef
  33. Baer RA, Smith GT, Hopkins J, Krietemeyer J, Toney L: Using self-report assessment methods to explore facets of mindfulness. / Assessment 2006,13(1):27鈥?5. CrossRef
  34. Neff KD: Development and validation of a scale to measure self-compassion. / Self and Identity 2003, 2:223鈥?50. CrossRef
  35. Treynor W, Gonzalez R, Nolen-Hoeksema S: Rumination reconsidered: A psychometric analysis. / Cognitive Therapy and Research 2003,27(3):247鈥?59. CrossRef
  36. Oliver JM, Baumgart EP: The Dysfunctional Attitude Scale - psychometric properties and relation to depression in an unselected adult-population. / Cognitive Therapy and Research 1985,9(2):161鈥?67. CrossRef
  37. Hayes SC, Strosahl K, Wilson KG, Bissett RT, Pistorello J, Toarmino D, Polusny MA, Dykstra TA, Batten SV, Bergan J, / et al.: Measuring Experiential Avoidance: A preliminary test of a working model. / Psychological Record 2004,54(4):553鈥?78.
  38. Carver CS, Lawrence JW, Scheier MF: Self-discrepancies and affect: Incorporating the role of feared selves. / Personality and Social Psychology Bulletin 1999,25(7):783鈥?92. CrossRef
  39. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/10/23/prepub
  
• 作者单位：J Mark G Williams (1)
  Ian T Russell (2) (3)
  Catherine Crane (1)
  Daphne Russell (3)
  Chris J Whitaker (3)
  Danielle S Duggan (1)
  Thorsten Barnhofer (1)
  Melanie JV Fennell (1)
  Rebecca Crane (4)
  Sarah Silverton (4)
  
  1. Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
  2. West Wales Organisation for Rigorous Trials in Health, School of Medicine, Swansea University, Swansea, SA2 8PP, UK
  3. North Wales Organisation for Randomised Trials in Health, Bangor University, Bangor, Gwynedd, LL57 2HX, UK
  4. School of Psychology, Bangor University, Gwynedd, LL57 1UT, UK
  

文摘

Background Depression is often a chronic relapsing condition, with relapse rates of 50-80% in those who have been depressed before. This is particularly problematic for those who become suicidal when depressed since habitual recurrence of suicidal thoughts increases likelihood of further acute suicidal episodes. Therefore the question how to prevent relapse is of particular urgency in this group. Methods/Design This trial compares Mindfulness-Based Cognitive Therapy (MBCT), a novel form of treatment combining mindfulness meditation and cognitive therapy for depression, with both Cognitive Psycho-Education (CPE), an equally plausible cognitive treatment but without meditation, and treatment as usual (TAU). It will test whether MBCT reduces the risk of relapse in recurrently depressed patients and the incidence of suicidal symptoms in those with a history of suicidality who do relapse. It recruits participants, screens them by telephone for main inclusion and exclusion criteria and, if they are eligible, invites them to a pre-treatment session to assess eligibility in more detail. This trial allocates eligible participants at random between MBCT and TAU, CPE and TAU, and TAU alone in a ratio of 2:2:1, stratified by presence of suicidal ideation or behaviour and current anti-depressant use. We aim to recruit sufficient participants to allow for retention of 300 following attrition. We deliver both active treatments in groups meeting for two hours every week for eight weeks. We shall estimate effects on rates of relapse and suicidal symptoms over 12 months following treatment and assess clinical status immediately after treatment, and three, six, nine and twelve months thereafter. Discussion This will be the first trial of MBCT to investigate whether MCBT is effective in preventing relapse to depression when compared with a control psychological treatment of equal plausibility; and to explore the use of MBCT for the most severe recurrent depression - that in people who become suicidal when depressed. Trial Registration Current Controlled Trials: ISRCTN97185214.