Electroencephalogram power changes as a correlate of chemotherapy-associated fatigue and cognitive dysfunction
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- 作者：Halle C. F. Moore (1)
Michael W. Parsons (1)
Guang H. Yue (1)
Lisa A. Rybicki (1)
Wlodzimierz Siemionow (1) - 关键词：Chemobrain ; Breast cancer ; Cognitive effects ; Fatigue
- 刊名：Supportive Care in Cancer
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：22
- 期：8
- 页码：2127-2131
- 全文大小：308 KB
- 参考文献：1. Mar Fan HG, Houede-Tchen N, Yi QL et al (2005) Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. J Clin Oncol 23:8025-032 CrossRef
2. Donovan KA, Small BJ, Andrykowski MA et al (2005) Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma. Cancer 104:2499-507 CrossRef
3. Arndt V, Merx H, Stegmaier C et al (2005) Persistence of restrictions in quality of life from the first to the third year after diagnosis in women with breast cancer. J Clin Oncol 23:4945-953 CrossRef
4. Ranganathan VK, Siemionow V, Davis M et al.: Cancer-related fatigue is associated with neuropsychological and neuromuscular junction impairments. Soc Neruosci Abstr, 398.9, 2005.
5. Siemionow V, Fang Y (2005) Calabrese et al.: altered central nervous system signal during motor performance in chronic fatigue syndrome. Clin Neurophysiol 115:2372-383 CrossRef
6. Mendoza TR, Wang XS, Cleeland CS et al (1999) The rapid assessment of fatigue severity in cancer patient: use of the Brief Fatigue Inventor. Cancer 1 85(5):1186-196
7. Beck AT, Steer RA, Brown GK: Beck Depression Inventory FastScreen for medical patients; The Psychological Corporation, 2000.
8. Bentall RP, Wood GC, Marrinan T et al (1993) A brief mental fatigue questionnaire. Br J Clin Psychol 32(Pt 3):375-79 CrossRef
9. Koppelmans V, Breteler M, Boogerd W et al (2012) Neuropsychological performance in survivors of breast cancer more than 20?years after adjuvant chemotherapy. J Clin Oncol 30:1080-086 CrossRef
10. Schagen SB, Muller MJ, Boogerd W et al (2002) Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patients. Ann Oncol 13:1387-397 CrossRef
11. Han SD, Bangen KJ, Bondi MW (2009) Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer’s disease: review and recommendations. Dement Geriatr Cogn Disord 27:1-0 CrossRef - 作者单位：Halle C. F. Moore (1)
Michael W. Parsons (1)
Guang H. Yue (1)
Lisa A. Rybicki (1)
Wlodzimierz Siemionow (1)
1. The Cleveland Clinic, Cleveland, OH, USA - ISSN：1433-7339
文摘
Purpose Persistent fatigue and cognitive dysfunction are poorly understood potential long-term effects of adjuvant chemotherapy. In this pilot study, we assessed the value of electroencephalogram (EEG) power measurements as a means to evaluate physical and mental fatigue associated with chemotherapy. Patients and methods Women planning to undergo adjuvant chemotherapy for breast cancer and healthy controls underwent neurophysiologic assessments at baseline, during the time of chemotherapy treatment, and at 1?year. Repeated measures analysis of variance was used to analyze the data. Results Compared with controls, patients reported more subjective fatigue at baseline that increased during chemotherapy and did not entirely resolve by 1?year. Performance on endurance testing was similar in patients versus controls at all time points; however, values of EEG power increased after a physical task in patients during chemotherapy but not controls. Compared with controls, subjective mental fatigue was similar for patients at baseline and 1?year but worsened during chemotherapy. Patients performed similarly to controls on formal cognitive testing at all time points, but EEG activity after the cognitive task was increased in patients only during chemotherapy. Conclusion EEG power measurement has the potential to provide a sensitive neurophysiologic correlate of cancer treatment-related fatigue and cognitive dysfunction.