Comparison of insulin sensitivity indices properties calculated from OGTT
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  • 作者:Jana Chrenova (1)
    Zuzana Rausova (1)
    Adela Penesova (2)
    Ladislav Dedik (1)
  • 关键词:Insulin sensitivity indices ; Point contrast ; Interval contrast ; Oral glucose tolerance test ; Body mass index (BMI)
  • 刊名:Central European Journal of Medicine
  • 出版年:2011
  • 出版时间:October 2011
  • 年:2011
  • 卷:6
  • 期:5
  • 页码:567-574
  • 全文大小:566KB
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  • 作者单位:Jana Chrenova (1)
    Zuzana Rausova (1)
    Adela Penesova (2)
    Ladislav Dedik (1)

    1. Institute of Automation, Measurement and Applied Informatics, Faculty of Mechanical Engineering, Slovak University of Technology, Bratislava, Slovak Republic
    2. Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic
文摘
The aim of this study was to present the properties of insulin sensitivity indices formulas to justify selection of formulas to evaluate of insulin sensitivity for calculation from an oral glucose tolerance test (OGTT) data. Twelve of the most applicable formulae for ISI calculation were analyzed in the view of two sets of results: 1) point contrasts, calculated as the ratio of average ISI values in lean and obese groups of patients; and 2) interval contrasts, calculated as ratios of T from the two-sided t-test, evaluated as dimensionless, mutually comparable contrasts within a continuous scale. Statistical significance of individual ISIs in terms of their contrasts was evaluated by two-sided t-tests. P<0.001 was a considered statistically significance between a group of 59 healthy volunteers with BMI<25 kg/m2 and a group of 63 volunteers with BMI?5 kg/m2 who underwent frequent OGTT sampling. To compare data of an individual subject with the standard, we recommend selecting the formulas with a high point contrast. To compare of data of several subject groups, we recommend using the formulas with a high interval contrast.

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