Interaction of Notch and gp130 Signaling in the Maintenance of Neural Stem and Progenitor Cells

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• 作者：Hana Kotasová (1)
  Ji?ina Procházková (1)
  Ji?í Pacherník (1) (2)
  
• 关键词：Neural stem cell ; Neural progenitor ; Signal transduction ; Notch ; gp130
• 刊名：Cellular and Molecular Neurobiology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：34
• 期：1
• 页码：1-15
• 全文大小：420 KB
• 作者单位：Hana Kotasová (1)
  Ji?ina Procházková (1)
  Ji?í Pacherník (1) (2)
  
  1. Faculty of Science, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic
  2. Center of Biomolecular and Cellular Engineering, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic
  
• ISSN：1573-6830

文摘

Notch and gp130 signaling are involved in the regulation of multiple cellular processes across various tissues during animal ontogenesis. In the developing nervous system, both signaling pathways intervene at many stages to determine cell fate—from the first neural lineage commitment and generation of neuronal precursors, to the terminal specification of cells as neurons and glia. In most cases, the effects of Notch and gp130 signaling in these processes are similar. The aim of the current review was to summarize the knowledge regarding the roles of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells during animal ontogenesis, from early embryo to adult. Recent data show a direct crosstalk between these signaling pathways that seems to be specific for a particular type of neural progenitors.