The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex
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- 作者：Erin Knock ; João Pereira ; Patrick D Lombard ; Andrew Dimond…
- 关键词：Neural progenitors ; Neural differentiation ; Gene expression
- 刊名：Neural Development
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：10
- 期：1
- 全文大小：3,638 KB
- 刊物主题：Neurosciences; Developmental Biology;
- 出版者：BioMed Central
- ISSN：1749-8104
文摘
Background Chromatin-modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. The methyl binding domain 3/nucleosome remodelling and deacetylation (MBD3/NuRD) co-repressor complex facilitates lineage commitment of pluripotent cells in early mouse embryos and is important for stem cell homeostasis in blood and skin, but its function in neurogenesis had not been described. Here, we show for the first time that MBD3/NuRD function is essential for normal neurogenesis in mice.