Serological and genetic complement alterations in infection-induced and complement-mediated hemolytic uremic syndrome
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- 作者：Dineke Westra ; Elena B. Volokhina ; Renate G. van der Molen…
- 关键词：Atypical HUS ; Complement ; Hemolytic uremic syndrome ; STEC ; Genetic aberrations ; Children
- 刊名：Pediatric Nephrology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：32
- 期：2
- 页码：297-309
- 全文大小：554KB
- 刊物类别：Medicine
- 刊物主题：Pediatrics; Nephrology; Urology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-198X
- 卷排序：32
文摘
BackgroundThe role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system, we hypothesized that complement dysregulation is also important in infection-induced HUS.