The high incidence of anti-Ro/SSA and anti-p200 antibodies in female patients with connective tissue diseases confirms the importance of screening for congenital heart block-associated autoantibodies during pregnancy

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• 作者：E. Cozzani ; Arianna Fay Agnoletti ; F. Pappalardo…
• 关键词：Anti ; p200 antibodies ; Anti ; Ro/SSA antibodies ; Cardiac complications ; Pregnancy screening ; Connective tissue disease
• 刊名：Archives of Dermatological Research
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：308
• 期：2
• 页码：139-143
• 全文大小：324 KB
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• 作者单位：E. Cozzani (1)
  Arianna Fay Agnoletti (1)
  F. Pappalardo (1)
  I. Schiavetti (2)
  A. Torino (1)
  A. Parodi (1)
  
  1. Section of Dermatology, IRCCS Azienda Ospedaliera Universitaria San Martino-IST, 16132, Genoa, Italy
  2. Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Dermatology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-069X

文摘

It is known that anti-Ro/SSA positivity leads to higher risk of miscarriage and fetal cardiac malformations. Particularly, anti-p200 antibodies against a finer specificity of the Ro/SSA antigen, have been associated with congenital heart block. The aim of the study was to assess the frequency of anti-p200 among female patients with different connective tissue diseases and, among these, the relevance of anti-p200 values in patients with cutaneous diseases compared to systemic diseases. Anti-p200 were investigated in 110 anti-Ro/SSA positive female sera, sent to our laboratory between 2008 and 2014 with suspect of connective disease, by using ELISA testing. Positivity was found in 40.9 % samples, 34 of them showed a strong positivity (values ≥ 1.0, cut off = 0.7). Patients with systemic diseases were anti-p200 positive in the 45.9 % of cases while patients with cutaneous diseases were positive in the 24.0 % of cases. Positivity for anti-p200 antibodies was revealed in 24.0 % of patients with discoid lupus erythematosus; 100 % of patients with dermatomyositis; 40.0 % of patients with mixed connective tissue disease; 25.0 % of patients with rheumatoid arthritis; 100 % of patients with Sjögren’s syndrome; 33.3 % of patients with subacute cutaneous lupus erythematosus; 42.9 % of patients with systemic lupus erythematosus; 80.0 % of patients with systemic sclerosis. No significant difference in anti-p200 prevalence was found between systemic and cutaneous involvement, nevertheless, considering only positive sera, the antibody titer was higher in systemic diseases rather than in cutaneous diseases (2.6 ± 1.7 and 1.7 ± 1.9; p = 0.041). The authors think screenings for anti-Ro/SSA and anti-p200 antibodies should be included in the laboratory checklist for pregnancy. Keywords Anti-p200 antibodies Anti-Ro/SSA antibodies Cardiac complications Pregnancy screening Connective tissue disease