RGD-conjugated silica-coated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer

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• 作者：Can Wang (1)
  Chenchen Bao (2)
  Shujing Liang (2)
  Hualin Fu (2)
  Kan Wang (2)
  Min Deng (2)
  Qiande Liao (1)
  Daxiang Cui (2)
  
  1. Xiangya Hospital of Central South University ; 87 Xiangya Road ; Changsha Hunan ; 410008 ; People鈥檚 Republic of China
  2. Institute of Nano Biomedicine and Engineering ; Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education ; Department of Instrument Science and Engineering ; Research Institute of Translation Medicine ; Shanghai JiaoTong University ; Dongchuan Road 800 ; Shanghai ; 200240 ; People鈥檚 Republic of China
  
• 关键词：RGD peptide ; Gold nanorods ; Multiwalled carbon nanotubes ; Optoacoustic imaging ; Gastric cancer ; Nude mice
• 刊名：Nanoscale Research Letters
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：9
• 期：1
• 全文大小：734 KB
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• 刊物主题：Nanotechnology; Nanotechnology and Microengineering; Nanoscale Science and Technology; Nanochemistry; Molecular Medicine;
• 出版者：Springer US
• ISSN：1556-276X

文摘

Herein, we reported for the first time that RGD-conjugated silica-coated gold nanorods on the surface of multiwalled carbon nanotubes were successfully used for targeted photoacoustic imaging of in vivo gastric cancer cells. A simple strategy was used to attach covalently silica-coated gold nanorods (sGNRs) onto the surface of multiwalled carbon nanotubes (MWNTs) to fabricate a hybrid nanostructure. The cross-linked reaction occurred through the combination of carboxyl groups on the MWNTs and the amino group on the surface of sGNRs modified with a silane coupling agent. RGD peptides were conjugated with the sGNR/MWNT nanostructure; resultant RGD-conjugated sGNR/MWNT probes were investigated for their influences on viability of MGC803 and GES-1 cells. The nude mice models loaded with gastric cancer cells were prepared, the RGD-conjugated sGNR/MWNT probes were injected into gastric cancer-bearing nude mice models via the tail vein, and the nude mice were observed by an optoacoustic imaging system. Results showed that RGD-conjugated sGNR/MWNT probes showed good water solubility and low cellular toxicity, could target in vivo gastric cancer cells, and obtained strong photoacoustic imaging in the nude model. RGD-conjugated sGNR/MWNT probes will own great potential in applications such as targeted photoacoustic imaging and photothermal therapy in the near future.