Drug Distribution Part 2. Predicting Volume of Distribution from Plasma Protein Binding and Membrane Partitioning

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• 作者：Ken Korzekwa ; Swati Nagar
• 关键词：KEY WORDSmicrosomal partitioning ; volume of distribution
• 刊名：Pharmaceutical Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：3
• 页码：544-551
• 全文大小：
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Pharmacology/Toxicology; Pharmacy; Biochemistry, general; Medical Law; Biomedical Engineering;
• 出版者：Springer US
• ISSN：1573-904X
• 卷排序：34

文摘

PurposeVolume of distribution is an important pharmacokinetic parameter in the distribution and half-life of a drug. Protein binding and lipid partitioning together determine drug distribution.