The evaluation of anti-angiogenic effects of Endostar on rabbit VX2 portal vein tumor thrombus using perfusion MSCT

详细信息    查看全文

• 作者：Guoquan Feng ; Zhen Lei ; Dongqing Wang ; Na Xu ; Qiang Wei ; Dinuo Li…
• 关键词：Tomography ; Perfusion imaging ; Portal vein tumor thrombus ; VX2 tumo ; Endostar ; Antiangiogenic treatment ; DCE ; CT
• 刊名：Cancer Imaging
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：14
• 期：1
• 全文大小：1270KB
• 参考文献：1.Ariizumi S, Yamamoto M: Prognostic impact of tumor encapsulation in patients with large hepatocellular carcinoma. J Surg Oncol 2012, 105:627. 10.1002/jso.23029CrossRef PubMed
  2.Chun YH, Ahn SH, Park JY, Kim do Y, Han KH, Chon CY, Byun SJ, Kim SU: Clinical characteristics and treatment outcomes of hepatocellular carcinoma with inferior vena cava/heart invasion. Anticancer Res 2011, 31:4641鈥?646.PubMed
  3.Luo JJ, Yan ZP, Wang JH, Liu QX, Qu XD, Zhang W: Endovascular placement of iodine-125 seed strand and self-expandable stent combined with transcatheter arterial chemoembolization for hepatocellular carcinoma with tumor thrombus in the main portal vein. Zhonghua Zhong Liu Za Zhi 2011, 33:535鈥?39.PubMed
  4.Cuenod C, Leconte I, Siauve N, Resten A, Dromain C, Poulet B, Frouin F, Clement O, Frija G: Early changes in liver perfusion caused by occult metastases in rats: detection with quantitative CT. Radiology 2001, 218:556鈥?61. 10.1148/radiology.218.2.r01fe10556CrossRef PubMed
  5.Fournier LS, Cuenod CA, de Bazelaire C, Siauve N, Rosty C, Tran PL, Frija G, Clement O: Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol 2004, 14:2125鈥?133. 10.1007/s00330-004-2339-8CrossRef PubMed
  6.Miles KA, Hayball MP, Dixon AK: Functional images of hepatic perfusion obtained with dynamic CT. Radiology 1993, 188:405鈥?11.CrossRef PubMed
  7.Kanematsu M, Osada S, Amaoka N, Goshima S, Kondo H, Nishibori H, Kato H, Matsuo M, Yokoyama R, Hoshi H, Moriyama N: Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: correlation with angiographically assisted CT. Am J Roentgenol 2004, 183:1585鈥?593. 10.2214/ajr.183.6.01831585CrossRef
  8.Park YN, Kim YB, Yang KM, Park C: Increased expression of vascular endothelial growth factor and angiogenesis in the early stage of multistep hepatocarcinogenesis. Arch Pathol Lab Med 2000, 124:1061鈥?065.PubMed
  9.Lei Z, Ma H, Xu N, Xi H: The evaluation of anti-angiogenic treatment effects for implanted rabbit VX2 breast tumors using functional multi-slice spiral computed tomography (f-MSCT). Eur J Radiol 2011, 78:277鈥?81. 10.1016/j.ejrad.2011.01.050CrossRef PubMed
  10.Amaoka N, Osada S, Kanematsu M, Imai H, Tomita H, Tokuyama Y, Sakashita F, Nonaka K, Goshima S, Kondo H, Adachi Y: Clinicopathological features of hepatocellular carcinoma evaluated by vascular endothelial growth factor expression. J Gastroenterol Hepatol 2007, 22:2202鈥?207. 10.1111/j.1440-1746.2006.04790.xCrossRef PubMed
  11.Veikkola T, Alitalo K: VEGFs, receptors and angiogenesis. Semin Canc Biol 1999, 9:211鈥?20. 10.1006/scbi.1998.0091CrossRef
  12.Samoto K, Ikezaki K, Ono M, Shono T, Kohno K, Kuwano M, Fukui M: Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Canc Res 1995, 55:1189鈥?193.
  13.Fuentes MA, Keith CJ, Griffiths M, Durbridge G, Miles KA: Hepatic haemodynamics: interrelationships between contrast enhancement and perfusion on CT and Doppler perfusion indices. Br J Radiol 2002, 75:17鈥?3.CrossRef PubMed
  14.Pandharipande PV, Krinsky GA, Rusinek H, Lee VS: Perfusion imaging of the liver: current challenges and future goals. Radiology 2005, 234:661鈥?73. 10.1148/radiol.2343031362CrossRef PubMed
  15.Purdie TG, Henderson E, Lee TY: Functional CT imaging of angiogenesis in rabbit VX2 soft-tissue tumour. Phys Med Biol 2001, 46:3161鈥?175. 10.1088/0031-9155/46/12/307CrossRef PubMed
  16.Amaoka N, Saio M, Nonaka K, Imai H, Tomita H, Sakashita F, Takahashi T, Sugiyama Y, Takami T, Adachi Y: Expression of vascular endothelial growth factor receptors is closely related to the histological grade of hepatocellular carcinoma. Oncol Rep 2006, 16:3鈥?0.PubMed
  17.Brodsky SV, Mendelev N, Melamed M, Ramaswamy G: Vascular density and VEGF expression in hepatic lesions. J Gastrointestin Liver Dis 2007, 16:373鈥?77.PubMed
  
• 作者单位：Guoquan Feng (6) (8)
  Zhen Lei (6)
  Dongqing Wang (8)
  Na Xu (6)
  Qiang Wei (6)
  Dinuo Li (7)
  Jingyi Liu (6)
  
  6. Radiology Department, the First Hospital of Liaoning Medical College, NO. 2, Wuduan, Renmin Street, Jinzhou, 121001, China
  8. Radiology Department, Affiliate Hospital of Jiangsu University, NO. 438, Jiefang Road, Zhenjiang, 212001, China
  7. Gastroenterology Department, the First Hospital of Liaoning Medical College, NO. 2, Wuduan, Renmin Street, Jinzhou, 121001, China
  
• 刊物类别：Imaging / Radiology; Cancer Research; Oncology;
• 刊物主题：Imaging / Radiology; Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1470-7330

文摘

Background There were many treatments for hepatocellular carcinoma with portal vein tumor thrombus (PVTT), in which targeted anti-angiogenic drug therapy is becoming a popular research topic. However, an objective and non-invasive method that can evaluate the treatment effects is still lacking.