Prevalence and trends of markers of hepatitis B virus, hepatitis C virus and human Immunodeficiency virus in Argentine blood donors
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- 作者：Diego M Flichman (1) (15)
Jorgelina L Blejer (2)
Beatriz I Livellara (3)
Viviana E Re (4)
Sonia Bartoli (5)
Juan A Bustos (6)
Claudia P Ansola (7)
Susana Hidalgo (8)
Martin E Cerda (9)
Alicia E Levin (7)
Adriana Huenul (10)
Victoria Riboldi (11)
Elena MC Trevi帽o (12)
Horacio J Salamone (13)
Felix A Nu帽ez (14)
Robert J Fern谩ndez (2)
Juan F Reybaud (13)
Rodolfo H Campos (1)
1. C谩tedra de Virolog铆a ; Universidad de Buenos Aires ; Buenos Aires ; Argentina
15. C谩tedra de Virolog铆a ; Universidad de Buenos Aires ; Jun铆n 956 - 4 piso ; ZIP code ; 1113 ; CABA ; Buenos Aires ; Argentina
2. Fundaci贸n Hemocentro ; Buenos Aires ; Argentina
3. Hospital Italiano Buenos Aires ; Buenos Aires ; Argentina
4. Universidad Nacional de C贸rdoba ; C贸rdoba ; Argentina
5. Centro regional de Hemoterapia Jujuy ; San Salvador de Jujuy ; Argentina
6. Banco de sangre San Jorge ; Ushuaia ; Argentina
7. Servicios de Hemoterapia de la provincia de Mendoza ; Mendoza ; Argentina
8. Hospital Dr Enrique Vera Barros ; La Rioja ; Argentina
9. Hospital Dr. Lucio Molas ; Santa Rosa ; Argentina
10. Hospital Art茅mides Zatti ; Viedma ; Argentina
11. Hospital Regional Rio Gallegos ; Rio Gallegos ; Argentina
12. Banco de Sangre de la Universidad Nacional de C贸rdoba ; C贸rdoba ; Argentina
13. Fundaci贸n Favaloro ; Buenos Aires ; Argentina
14. Servicio de Hemoterapia del Hospital Italiano ; Buenos Aires ; Argentina - 关键词：Prevalence ; Trend ; Blood donors ; HIV ; HBV ; HCV
- 刊名：BMC Infectious Diseases
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：14
- 期：1
- 全文大小：237 KB
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44. The pre-publication history for this paper can be accessed here: lass="a-plus-plus">http://www.biomedcentral.com/1471-2334/14/218/prepub - 刊物主题：Infectious Diseases; Parasitology; Medical Microbiology; Tropical Medicine; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2334
文摘
Background Transfusion-transmitted infections are a major problem associated with blood transfusion. The aim of this study was to determine prevalence and trends of HBV, HCV and HIV in blood donors in Argentina. Methods A retrospective study was carried out in blood donors of 27 transfusion centers covering the whole country over a period of eight years (2004-2011). Serologic screening assays for HBsAg, anti-HBc, anti-HCV, and anti-HIV were performed in all centers and nucleic acid amplification testing (NAT) was performed in 2 out of the 27 centers. Results The 2,595,852 samples tested nationwide from 2004 to 2011 showed that the prevalence of HBsAg decreased from 0.336% to 0.198% (p Conclusions Argentina has a low prevalence of HBsAg, anti-HCV and anti-HIV in blood donors, with a decreasing trend for HBsAg, anti-HBc and anti-HCV but not for anti-HIV over the last 8 years. The uneven distribution of transfusion-transmitted infections prevalence among the different regions of the country highlights the need to implement regional awareness campaigns and prevention. The discrepancy between samples testing positive for screening assays and negative for NAT assays highlights the problem of blood donors who test repeatedly reactive in screening assays but are not confirmed as positive upon further testing. The uneven distribution of age between healthy donors and NAT-positive donors could be related to changes in risks of these pathogens in the general population and might be attributed to a longer exposure to transmission risk factors in elderly people.