Biodegradable Poly(ε-Caprolactone)-Based Graft Copolymers Via Poly(Linoleic Acid): In Vitro Enzymatic Evaluation

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• 作者：Sema All? ; R. Seda T??l? Ayd?n…
• 关键词：Enzymatic degradation ; Poly(ε ; caprolactone) ; Poly(linoleic acid) ; Poly(styrene)
• 刊名：Journal of the American Oil Chemists' Society
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：92
• 期：3
• 页码：449-458
• 全文大小：2,377 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Industrial Chemistry and Chemical Engineering
  Analytical Chemistry
  Chemistry
  Biotechnology
  Biomaterials
  Agriculture
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1558-9331

文摘

Well-defined graft copolymers based on poly(ε-caprolactone) (PCL) via poly(linoleic acid) (PLina), are derived from soybean oil. Poly(linoleic acid)-g-poly(ε-caprolactone) (PLina-g-PCL) and poly(linoleic acid)-g-poly(styrene)-g-poly(ε-caprolactone) (PLina-g-PSt-g-PCL) were synthesized by ring-opening polymerization of ε-caprolactone initiated by PLina and one-pot synthesis of graft copolymers, and by ring-opening polymerization and free radical polymerization by using PLina, respectively. PLina-g-PCL, PLina-g-PSt-g-PCL3, and PLina-g-PSt-g-PCL4 copolymers containing 96.97, 75.04 and 80.34?mol% CL, respectively, have been investigated regarding their enzymatic degradation properties in the presence of Pseudomonas lipase. In terms of weight loss, after 1?month, 51.5?% of PLina-g-PCL, 18.8?% of PLina-g-PSt-g-PCL3, and 38.4?% of PLina-g-PSt-g-PCL4 were degraded, leaving remaining copolymers with molecular weights of 16,140, 83,220 and 70,600?Da, respectively. Introducing the PLina unit into the copolymers greatly decreased the degradation rate. The molar ratio of [CL]/[Lina] dramatically decreased, from 21.3 to 8.4, after 30?days of incubation. Moreover, reduced PCL content in PLina-g-PSt-g-PCL copolymers decreased the degradation rate, probably due to the PSt enrichment within the structure, which blocks lipase contact with PCL units. Thus, copolymerization of PCL with PLina and PSt units leads to a controllable degradation profile, which encourages the use of these polymers as promising biomaterials for tissue engineering applications.