Association Between Single Nucleotide Polymorphism +276G聽>聽T (rs1501299) in ADIPOQ and Endometrial Cancer

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• 作者：Jan Bie艅kiewicz ; Beata Smolarz ; Andrzej Malinowski
• 关键词：Endometrial cancer ; Single nucleotide polymorphism ; 聽+聽276G聽> ; 聽T ; Obesity ; Adiponectin ; ADIPOQ
• 刊名：Pathology & Oncology Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：22
• 期：1
• 页码：135-138
• 全文大小：253 KB
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• 作者单位：Jan Bie艅kiewicz (1)
  Beata Smolarz (2)
  Andrzej Malinowski (1)
  
  1. Department of Surgical & Endoscopic Gynecology and Gynecologic Oncology, Polish Mothers鈥?Memorial Hospital-Research Institute, Lodz, Poland
  2. Laboratory of Molecular Genetics, Department of Pathology, Polish Mothers鈥?Memorial Hospital-Research Institute, Lodz, Poland
  
• 刊物主题：Cancer Research; Oncology; Pathology; Immunology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1532-2807

文摘

Current literature gives evidence of an indisputable role adiponectin plays in adipose tissue metabolism and obesity-related diseases. Moreover, latest research efforts focus on linking genetic markers of this adipocytokine鈥檚 gene (ADIPOQ) with cancer. Aim of this study was to determine the genotype distribution of single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ and an attempt to identify the impact this polymorphism exerts on endometrial cancer risk in obese females. The test group comprised 90 women treated surgically for endometrial cancer between 2000 and 2012 in the Department of Surgical & Endoscopic Gynecology and Gynecologic Oncology, Polish Mothers鈥?Memorial Hospital - Research Institute, Lodz, Poland. 90 individuals treated in the parallel period for uterine fibroids constituted the control group. Patients within both groups were stratified according to BMI into: lean, overweight and obese subjects. Statistical analysis was performed between two major groups and, furthermore, within the abovementioned subgroups. The analysis revealed that allele G of the investigated polymorphism in obese women with endometrial cancer is significantly more frequent, and allele T is significantly less frequent than in lean controls. However, no significant correlation was observed between the polymorphism and endometrial cancer in lean and overweight females. Single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ may be considered to be a risk factor of endometrial cancer. Further research on SNP in EC is warranted to obtain more conclusive outcomes. Keywords Endometrial cancer Single nucleotide polymorphism + 276G > T Obesity Adiponectin ADIPOQ