Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome

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• 作者：Juan Wang ; Huiyong Peng ; Jie Tian ; Jie Ma ; Xinyi Tang ; Ke Rui…
• 关键词：Long noncoding RNA ; TMEVPG1 ; T helper type 1 cells ; Sjögren syndrome
• 刊名：Immunologic Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：64
• 期：2
• 页码：489-496
• 全文大小：723 KB
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• 作者单位：Juan Wang (1) (2)
  Huiyong Peng (1)
  Jie Tian (2)
  Jie Ma (2)
  Xinyi Tang (1)
  Ke Rui (2)
  Xinyu Tian (2)
  Yungang Wang (2)
  Jianguo Chen (1)
  Liwei Lu (3)
  Huaxi Xu (2)
  Shengjun Wang (1) (2)
  
  1. Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Dianli Road 8, Zhenjiang, 212002, China
  2. Institute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China
  3. Department of Pathology, The University of Hong Kong, Hong Kong, China
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Long noncoding RNAs (lncRNA) play key roles in regulating autoimmunity and immunity balance. LncRNA TMEVPG1, which is encoded by a gene located near the Ifn gene, contributes to interferon gamma expression. We investigated the expression of TMEVPG1 in patients with Sjögren syndrome (SS) to determine its role in the pathogenesis of SS. In this study, we detected the relative expression of TMEVPG1 in CD4+ T cells of 25 SS patients and 25 healthy donors. Moreover, the proportion of Th1 cells and T-bet levels was also analyzed. Furthermore, we explored the correlation between the expression of TMEVPG1 and the level of autoantibodies, erythrocyte sedimentation rate (ESR) and IgG in SS patients. Our results indicated that the proportion of Th1 cells and the levels of TMEVPG1 and T-bet were increased in SS patients. In addition, the level of expression of TMEVPG1 was correlated with the level of SSA, ESR and IgG. Our data suggest that upregulation of lncRNA TMEVPG1 may be involved in the pathogenesis of Sjögren syndrome.