Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy
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- 作者：Men-Bao Qian (9)
Peiling Yap (10) (11)
Yi-Chao Yang (12)
Hai Liang (13)
Zhi-Hua Jiang (12)
Wei Li (13)
Jürg Utzinger (10) (11)
Xiao-Nong Zhou (9)
Jennifer Keiser (11) (14) - 关键词：Clonorchis sinensis ; Kato ; Katz method ; Formalin ; ether concentration technique ; Diagnosis ; Efficacy
- 刊名：Parasites & Vectors
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：6
- 期：1
- 全文大小：196 KB
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Peiling Yap (10) (11)
Yi-Chao Yang (12)
Hai Liang (13)
Zhi-Hua Jiang (12)
Wei Li (13)
Jürg Utzinger (10) (11)
Xiao-Nong Zhou (9)
Jennifer Keiser (11) (14)
9. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborative Center for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People’s Republic of China
10. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
11. University of Basel, Basel, Switzerland
12. Guangxi Center for Disease Control and Prevention, Nanning, People’s Republic of China
13. Binyang Center for Disease Control and Prevention, Binyang, People’s Republic of China
14. Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland - ISSN：1756-3305
文摘
Background Clonorchiasis is a chronic neglected disease caused by a liver fluke, Clonorchis sinensis. Chemotherapy is the mainstay of control and treatment efficacy is usually determined by microscopic examination of fecal samples. We assessed the diagnostic accuracy of the Kato-Katz method and the formalin-ether concentration technique (FECT) for C. sinensis diagnosis, and studied the effect of diagnostic approach on drug efficacy evaluation. Methods Overall, 74 individuals aged ?8?years with a parasitological confirmed C. sinensis infection at baseline were re-examined 3?weeks after treatment. Before and after treatment, two stool samples were obtained from each participant and each sample was subjected to triplicate Kato-Katz thick smears and a single FECT examination. Results Thirty-eight individuals were still positive for C. sinensis according to our diagnostic ‘gold-standard (six Kato-Katz thick smears plus two FECT). Two FECT had a significantly lower sensitivity than six Kato-Katz thick smears (44.7% versus 92.1%; p <0.001). Examination of single Kato-Katz and single FECT considerably overestimated cure rates. Conclusions In settings where molecular diagnostic assays are absent, multiple Kato-Katz thick smears should be examined for an accurate diagnosis of C. sinensis infection and for assessing drug efficacy against this liver fluke infection.