Comparison of digital image analysis and visual scoring of KI-67 in prostate cancer prognosis after prostatectomy

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• 作者：Patrice Desmeules ; Hélène Hovington ; Molière Nguilé-Makao…
• 关键词：Prostate cancer ; Proliferation ; Biochemical recurrence ; Mortality ; Digital image analysis
• 刊名：Diagnostic Pathology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：10
• 期：1
• 全文大小：1,105 KB
• 刊物主题：Pathology;
• 出版者：BioMed Central
• ISSN：1746-1596

文摘

Background The tumor proliferative index marker Ki-67 was shown to be associated with clinically significant outcomes in prostate cancer, but its clinical application has limitations due to lack of uniformity and consistency in quantification. Our objective was to compare the measurements obtained with digital image analysis (DIA) versus virtual microscopy (visual scoring (VS)).