Puberty and testosterone shape the corticospinal tract during male adolescence
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- 作者：Melissa M. Pangelinan ; Gabriel Leonard ; Michel Perron…
- 关键词：MRI ; Magnetization transfer ; White matter ; Development
- 刊名：Brain Structure and Function
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：221
- 期：2
- 页码：1083-1094
- 全文大小：953 KB
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Gabriel Leonard (2)
Michel Perron (3) (4)
G. Bruce Pike (5)
Louis Richer (4)
Suzanne Veillette (3) (4)
Zdenka Pausova (6)
Tomáš Paus (1) (7)
1. Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, ON, M6A 2E1, Canada
2. Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A 2B4, Canada
3. ECOBES, Céjep de Jonquière, 2505 Rue Saint Hubert, Jonquière, QC, G7X 3W1, Canada
4. Département des Sciences de la Santé, Université du Québec à Chicoutimi, 555 Boulevard de l’Université, Chicoutimi, QC, G7H 2B1, Canada
5. Faculty of Medicine, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
6. The Hospital of Sick Children, Toronto, ON, M5G 1X8, Canada
7. Departments of Psychology and Psychiatry, University of Toronto, 100 St. George Street, Toronto, ON, M5S 3G3, Canada - 刊物主题：Neurosciences; Cell Biology; Neurology;
- 出版者：Springer Berlin Heidelberg
- ISSN：1863-2661
文摘
Some of the known sex differences in white matter emerge during adolescence. Here, we replicate and extend our previous findings of sex differences in the structure of the corticospinal tract (Perrin et al. 2009; Hervé et al. 2009). In a large normative sample of adolescents, we observed age × sex interactions in the signal intensity of T1-weighted (T1W) images (n = 941) and in magnetization transfer ratio (MTR; n = 761); both features were inversely associated with age in males but not in females. Moreover, we hypothesized that the age-related differences in CST structure exhibited by males would be mediated by differences in puberty stage and levels of bioavailable testosterone. We confirmed this prediction using mediation analysis with bootstrapping. These findings suggest that sex differences in the CST structure observed during male adolescence may be due to multiple processes associated with puberty, including (but not limited to) the rising levels of testosterone.