Mouse models of lung squamous cell carcinomas

详细信息    查看全文

• 作者：Michael S. You ; Lucina C. Rouggly ; Ming You ; Yian Wang
• 关键词：Mouse models ; Lung squamous cell carcinoma ; Chemical ; induced ; Transgenic ; Chemoprevention
• 刊名：Cancer and Metastasis Reviews
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：32
• 期：1-2
• 页码：77-82
• 全文大小：311KB
• 参考文献：1. Wang, Y., Zhang, Z., Yan, Y., Lemon, W. J., LaRegina, M., Morrison, C., et al. (2004). A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. / Cancer Research, 64, 1647-654.
  2. Ji, H., Ramsey, M. R., Hayes, D. N., Fan, C., McNamara, K., Kozlowski, P., et al. (2007). LKB1 modulates lung cancer differentiation and metastasis. / Nature, 448, 807-10. CrossRef
  3. Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010). Cancer Statistics, 2010. / CA: A Cancer Journal for Clinicians, 60, 277-00. CrossRef
  4. Doll, R., & Hill, A. (1954). The mortality of doctors in relation to their smoking habits; a preliminary report. / British Medical Journal, 1, 1451-455. CrossRef
  5. Herzog, C. R., Lubet, R. A., & You, M. (1997). Genetic alterations in mouse lung tumors: implications for cancer chemoprevention. / Journal of Cellular Biochemistry. Supplement, 28-9, 49-3. CrossRef
  6. Witschi, H. P., Espiritu, I., Maronpot, R. R., Pinkerton, K. E., & Jones, A. D. (1997). The carcinogenic potential of the gas phase of environmental tobacco smoke. / Carcinogenesis, 18, 2035-042. CrossRef
  7. Witschi, H., Espiritu, I., Peake, J. L., Wu, K., Maronpot, R. R., & Pinkerton, K. E. (1997). The carcinogenicity of environmental tobacco smoke. / Carcinogenesis, 18, 575-86. CrossRef
  8. Shopland, D. R., Fyre, J., II, & Pechacek, T. F. (1991). Smoking attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States. / Journal of the National Cancer Institute, 83, 1142-147. CrossRef
  9. Doll, R., & Hill, A. (1952). A study of the aetiology of carcinoma of the lung. / British Medical Journal, ii, 1271-286. CrossRef
  10. Minna, J. D. (1993). The molecular biology of lung cancer pathogenesis. / Chest, 103, 449-56. CrossRef
  11. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., Smigal, C., et al. (2006). Cancer statistics, 2006. / CA: A Cancer Journal for Clinicians, 56, 106-30. CrossRef
  12. Hong, W. K., & Sporn, M. B. (1997). Recent advances in chemoprevention of cancer. / Science, 278, 1073-077. CrossRef
  13. Travis, W. D., Travis, L. B., & Devesa, S. S. (1995). Lung cancer. / Cancer, 75, 191-02. CrossRef
  14. Malkinson, A. M. (1992). Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma. / Cancer Research, 52, 2670s-676s.
  15. Auerbach, O., Forman, J. B., Gere, J. B., Kassouny, D. Y., Muehsam, G. E., Petrick, T. G., et al. (1957). Changes in the bronchial epithelium in relation to smoking and cancer of the lung; a report of progress. / The New England Journal of Medicine, 256, 97-04. CrossRef
  16. Auerbach, O., Stout, A. P., Hammond, E. C., & Garfinkel, L. (1961). Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. / The New England Journal of Medicine, 265, 253-67. CrossRef
  17. Saccomanno, G., Archer, V. E., Auerbach, O., Saunders, R. P., & Brennan, L. M. (1974). Development of carcinoma of the lung as reflected in exfoliated cells. / Cancer (Philadelphia), 33, 256-70. CrossRef
  18. Becci, P. J., McDowell, E. M., & Trump, B. F. (1978). The respiratory epithelium. VI. Histogenesis of lung tumors induced by benzo[a]pyrene-ferric oxide in the hamster. / Journal of the National Cancer Institute (Bethesda), 61, 607-18.
  19. No authors (1986). Tobacco smoking. IARC Monogr. Eval. Carcinog. / Risk of Chemical Human 38, 35-94.
  20. Hammar, S. P., Bolen, J. W., Bockus, D., Remington, F., & Friedman, S. (1985). Ultrastructural and immunohistochemical features of common lung tumors: an overview. / Ultrastructural Pathology, 9, 283-18. CrossRef
  21. Chao, A., Thun, M. J., Jacobs, E. J., Henley, S. J., Rodriguez, C., & Calle, E. E. (2000). Cigarette smoking and colorectal cancer mortality in the cancer prevention study II. / Journal of the National Cancer Institute (Bethesda), 92, 1888-896. CrossRef
  22. Yoshimoto, T., Hirao, F., Sakatani, M., Nishikawa, H., & Ogura, T. (1977). Induction of squamous cell carcinoma in the lung of C57BL/6 mice by intratracheal instillation of benzo[a]pyrene with charcoal powder. / Gann, 68, 343-52.
  23. Yoshimoto, T., Inoue, T., Iizuka, H., Nishikawa, H., Sakatani, M., Ogura, T., et al. (1980). Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. / Cancer Research, 40, 4301-307.
  24. Henry, C. J., Billups, L. H., Avery, M. D., Rude, T. H., Dansie, D. R., Lopez, A., et al. (1981). Lung cancer model system using 3-methylcholanthrene in inbred strains of mice. / Cancer Research, 41, 5027-032.
  25. Lijinsky, W., & Reuber, M. D. (1988). Neoplasms of the skin and other organs observed in Swiss mice treated with nitrosoalkylureas. / Journal of Cancer Research and Clinical Oncology, 114, 245-49. CrossRef
  26. You, M., & Bergman, G. (1998). Preclinical and clinical models of lung cancer chemoprevention. / Hematology/Oncology Clinics of North America, 12, 1037-053. CrossRef
  27. Wang, Y., Zhang, Z., Garbow, J. R., Rowland, D. J., Lubet, R. A., Sit, D., et al. (2009). Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. / Cancer Prevention Research (Philadelphia, PA), 2, 634-40. CrossRef
  28. Wang, Y., James, M., Wen, W., Lu, Y., Szabo, E., Lubet, R. A., et al. (2010). Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. / Molecular Cancer Therapeutics, 9, 3074-082. CrossRef
  29. Hudish, T. M., Opincariu, L. I., Mozer, A. B., Johnson, M. S., Cleaver, T. G., Malkoski, S. P., et al. (2012). / N-nitroso-trischloroethylurea induces premalignant squamous dysplasia in mice. / Cancer Prevention Research (Philadelphia, Pa.), 5, 283-89. CrossRef
  30. Launonen, V. (2005). Mutations in the human LKB1/STK11 gene. / Human Mutation, 26, 291-97. Review. CrossRef
  31. Farago, A. F., Snyder, E. L., & Jacks, T. (2012). SnapShot: lung cancer models. / Cell, 149, 246-46.e1.
  32. Rehm, S., Lijinsky, W., Singh, G., & Katyal, S. L. (1991). Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by / N-nitrosobis-(2-chloroethyl) ureas. / The American Journal of Pathology, 139, 413-22.
  33. Khan, N., Afaq, F., Kweon, M. H., Kim, K., & Mukhtar, H. (2007). Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. / Cancer Research, 67, 3475-482. CrossRef
  34. Ambrosini, V., Nanni, C., Pettinato, C., Fini, M., D’Errico, A., Trepidi, S., et al. (2007). Assessment of a chemically induced model of lung squamous cell carcinoma in mice by 18F-FDG small-animal PET. / Nuclear Medicine Communications, 28, 647-52.
  
• 作者单位：Michael S. You (1)
  Lucina C. Rouggly (1)
  Ming You (2)
  Yian Wang (1) (3)
  
  1. Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA
  2. Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
  3. Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO, 63110, USA
  
• ISSN：1573-7233

文摘

Although many mouse models of lung adenocarcinoma exist, only a few mouse lung squamous cell carcinoma models have been developed. Since most clinical chemoprevention trials of lung cancer are performed in subjects with bronchial dysplasia, development of a lung squamous cell carcinoma mouse model sufficient for chemoprevention studies is a high priority. We have shown that lung squamous cell carcinomas can be induced chemically in several strains of mice (1), and that this chemically induced lung squamous cell carcinoma model is applicable to cancer chemoprevention studies. Recently, Ji et al. (2) have shown that simultaneous activation of KrasG12D and inactivation of Lkb1 results in a broader histological range of lung tumors, with approximately 50?% of the lung tumors being squamous cell carcinomas. Here, we review the application of mouse lung squamous cell carcinoma models with different stages of squamous lesions and squamous cell carcinomas to cancer development and chemoprevention studies.