Electrophoretic separation of some nucleosides for the diagnosis of mastopathy and fibroadenoma
详细信息 查看全文
- 作者：Mingsheng Jiang ; A. F. Prokhorova ; N. B. Rozhmanova…
- 关键词：tumor markers ; diagnosis of cancer ; nucleosides ; urine ; micellar electrokinetic chromatography
- 刊名：Journal of Analytical Chemistry
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：71
- 期：12
- 页码：1198-1203
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Analytical Chemistry;
- 出版者：Pleiades Publishing
- ISSN：1608-3199
- 卷排序：71
文摘
Mixtures of 13 normal and modified nucleosides in a 70 mM phosphate buffer solution (pH 6.7) supplemented with 100 mM of sodium dodecyl sulfate were separated by micellar electrokinetic chromatography in 25 min. Electrophoretic profiles of urine are obtained; it is demonstrated that 1-methylinosine and 1-methylguanosine nucleosides can be used as markers of precancerous states (mastopathy) and benign tumors (fibroadenoma).