Augmenter of liver regeneration attenuates inflammation of renal ischemia/reperfusion injury through the NF-kappa B pathway in rats

详细信息    查看全文

• 作者：Ruyu Yan ; Ying Li ; Ling Zhang ; Ning Xia ; Qi Liu…
• 关键词：Acute kidney injury ; Ischemia reperfusion injury ; Augmenter of liver regeneration ; Inflammation
• 刊名：International Urology and Nephrology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：47
• 期：5
• 页码：861-868
• 全文大小：2,320 KB
• 参考文献：1.Bonventre JV, Zuk A (2004) Ischemic acute renal failure: an inflammatory disease? Kidney Int 66:480-85View Article PubMed
  2.Kinsey GR, Li L, Okusa MD (2008) Inflammation in acute kidney injury. Exp Nephrol 109:102-07View Article
  3.Dorweiler B, Pruefer D, Andrasi TB, Maksan SM, Schmiedt W et al (2007) Ischemia-reperfusion injury. Eur J Trauma Emerg Surg 33:600-12View Article
  4.Kato A, Gabay C, Okaya T, Lentsch AB (2002) Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion. Am J Pathol 161:1797-803View Article PubMed Central PubMed
  5.Maekawa N, Wada H, Kanda T, Niwa T, Yamada Y et al (2002) Improved myocardial ischemia/reperfusion injury in mice lacking tumor necrosis factor-α. J Am Coll Cardiol 39:1229-235View Article PubMed
  6.Baldwin AS Jr (1996) The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-83View Article PubMed
  7.Gandhi CR (2012) Augmenter of liver regeneration. Fibrogenesis Tissue Repair 5:10-1View Article PubMed Central PubMed
  8.Liao X-H, Zhang L, Tang X-P, Liu Q, Sun H (2009) Expression of augmenter of liver regeneration in rats with gentamicin-induced acute renal failure and its protective effect on kidney. Ren Fail 31:946-55View Article PubMed
  9.Liao Xh, Zhang L, Liu Q, Sun H, Cm Peng et al (2010) Augmenter of liver regeneration protects kidneys from ischaemia/reperfusion injury in rats. Nephrol Dial Transplant 25:2921-929View Article PubMed
  10.Kasagi N et al (1994) Apoptotic cell death in human gastric carcinoma: analysis by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. Jpn J Cancer Res 85:939-45View Article PubMed
  11.Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z et al (2013) Acute kidney injury: an increasing global concern. Lancet 382:170-79View Article PubMed
  12.Munshi R, Hsu C, Himmelfarb J (2011) Advances in understanding ischemic acute kidney injury. BMC Med 9:5-1View Article
  13.Grigoryev DN, Liu M, Hassoun HT, Cheadle C, Barnes KC et al (2008) The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol 19:547-58View Article PubMed Central PubMed
  14.Gerlach UA, Atanasov G, Wallenta L, Polenz D, Reutzel-Selke A et al (2014) Short-term TNF-alpha inhibition reduces short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation. Transplantation 97:732-39View Article PubMed
  15.Long D, Hsu Y-H, Li H-H, Sung J-M, Chen W-T et al (2013) Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. PLoS One 8:e56028. doi:10.-371/?journal.?pone.-056028
  16.Dong X, Swaminathan S, Bachman LA, Croatt AJ, Nath KA et al (2007) Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 71:619-28View Article PubMed
  17.Hagiya M, Francavilla A, Polimeno L et al (1994) Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution. Proc Natl Acad Sci USA 91:8142-146View Article PubMed Central PubMed
  18.Khandoga A, Mende K, Iskandarov E, Rosentreter D, Schelcher C et al (2014) Augmenter of liver regeneration attenuates inflammatory response in the postischemic mouse liver in vivo. J Surg Res 10:1016
  19.Wang N, Wang Z, Sun H, Shi X, Zhang Y et al (2013) Augmenter of liver regeneration improves therapeutic effect of hepatocyte homotransplantation in acute liver failure rats. Int Immunopharmacol 15:325-32View Article PubMed
  20.Li Y, Zhang L, Liu Q, Chen GT, Sun H (2014) Exogenous augmenter of liver regeneration (ALR) attenuates inflammatory response in renal hypoxia re-oxygenation injury. Ren Fail 36:432-36View Article PubMed
  21.Lawrence T (2009) The nuclear factor NF- B pathway in inflammation. Cold Spring Harb Perspect Biol 1. doi:10.-101/?cshperspect.?a001651
  22.Sung FL, Zhu TY, Au-Yeung KK, Siow YL, Karmin O (2002) Enhanced MCP-1 expression during ischemia/reperfusion injury is mediated by oxidative stress and NF-kappa B. Kidney Int 62:1160-170View Article PubMed
  23.Gasparini C, Feldmann M (2012) NF-kappa B as a target for modulating inflammatory responses. Curr Pharm Des 18:5735-745View Article PubMed
  24.Luo JG, Zhao XL, Xu WC, Zhao XJ, Wang JN et al (2014) Spinal nuclear factor-kappa B (NF-kappa B) p65 activation contributes to peripheral inflammation and hyperalgesia in rat adjuvant-induced arthritis. Arthritis Rheum 66:896-06View Article
  25.Gandhi CR, Murase N, Starzl TE (2010) Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat kupffer cells. J Cell Physiol 222:365-73View Article PubMed Central PubMed
  26.Yang K, Du C, Cheng Y, Li Y, Gong J et al (2013) Augmenter of liver regeneration promotes hepatic regeneration depend
• 作者单位：Ruyu Yan (1)
  Ying Li (1)
  Ling Zhang (1)
  Ning Xia (1)
  Qi Liu (2)
  Hang Sun (2)
  Hui Guo (2)
  
  1. Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China
  2. Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400010, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nephrology
  Urology and Andrology
  
• 出版者：Springer Netherlands
• ISSN：1573-2584

文摘

Purpose The effects of augmenter of liver regeneration (ALR) on the acute kidney injury (AKI) rats were investigated by measuring the inflammatory response associated with transcription factor nuclear factory (NF-κB) pathway. Methods The model of AKI rats was established by occluded the renal pedicles for 60?min and then released. After that, animals were treated with ALR (100 or 200?μg/kg). All rats were killed at different time points (24, 48, 72?h). Renal function and kidney histological changes were measured. The apoptosis of tubular cells was evaluated by TdT-mediated dUTP nick end labeling assay. Cytokines and chemokines were assessed by immunohistochemistry, enzyme-linked immunosorbent assay and real-time polymerase chain reaction (RT-PCR). The NF-κB p65 protein was analyzed by immunohistochemistry and RT-PCR, respectively. Results Ischemia reperfusion induced tubular cells necrosis and apoptosis, and ALR can significantly reduce this damages. The productions of MCP-1, IL-1β and IL-6 were lower in the group of ALR treatment, especially in the high-dose group. The inflammatory infiltrates were lower in the rats with administration of ALR. ALR mediated the level of cytokines and chemokines through inhibited the activation of NF-κB. Conclusion ALR can improve renal function and inhibit the expression of inflammatory factors. This protects against renal ischemia reperfusion injury, which may be associated with preventing NF-κB activation in rats.