Modeling the Effects of Dopamine on the Antisaccade Reaction Times (aSRT) of Schizophrenia Patients

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• 作者：Ioannis Kahramanoglou ; Stavros Perantonis ; Nikolaos Smyrnis ; Ioannis Evdokimidis ; Vassilis Cutsuridis
• 关键词：Accumulator model ; schizophrenia ; antisaccade task ; reaction times ; dopamine ; cortex ; superior colliculus ; pyramidal cells ; inhibitory interneurons
• 刊名：Lecture Notes in Computer Science
• 出版年：2008
• 出版时间：2008
• 年：2008
• 卷：5164
• 期：1
• 页码：290-299
• 全文大小：183.3 KB

文摘

In the antisaccade task, subjects are instructed to look in the opposite direction of a visually presented stimulus. Controls can perform this task successfully with very few errors, whereas schizophrenia patients make more errors and their responses are slower and more variable. It has been proposed the fundamental cognitive dysfunction in schizophrenia involves prefrontal dopaminergic hypoactivity. We examine via computer simulations the effects of dopamine on the variability of aSRTs in a neural cortico-collicular accumulator model with stochastic climbing activity. We report the simulated aSRTs for the hypo-DA level have higher standard deviation and mean values than in the normal and hyper DA level. The simulated higher mean and standard deviation for the hypo-DA group resemble the performance differences in the antisaccade task observed in patients with schizophrenia and are in accordance with the theory of a hypo-DA state in the frontal cortical areas of patients with schizophrenia.