Cystatin C is a suitable marker of glomerular function in children with cancer

详细信息    查看全文

• 作者：Edit Bárdi ; Ildikó Bobok ; Anna V. Oláh ; éva Oláh ; János Kappelmayer and Csongor Kiss
• 关键词：Cystatin C ; Glomerular function ; Childhood cancer
• 刊名：Pediatric Nephrology
• 出版年：2004
• 出版时间：October 2004
• 年：2004
• 卷：19
• 期：10
• 页码：1145-1147
• 全文大小：137 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Pediatrics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-198X

文摘

Antineoplastic chemotherapy is associated with nephrotoxic side effects. Data on nephrotoxicity in childhood cancer are scanty, in part because of the difficulties in obtaining reliable markers of glomerular function. We used serum cystatin C (cysC) to assess glomerular function. CysC was compared with serum creatinine concentration (S_Cr), the endogenous creatinine clearence ( C _Cr), and the calculated Counahan formula ( C _Counahan) in children with leukemia and solid tumors. CysC was measured by particle-enhanced immunoturbidimetric assay. Serum and urinary creatinine concentrations were determined by the Jaffé method. Samples were obtained from 258 children, including 92 receiving anticancer chemotherapy, 108 long-term survivors, 40 children without any renal disease, and 18 patients with chronic renal insufficiency. CysC of patients on current chemotherapy was assessed both before and after treatment. Significant correlations were found between cysC and S_Cr and between 1/cysC and C _Counahan. CysC increased significantly after cisplatin, methotrexate, cyclophosphamide, ifosfamide, and multimodality treatment. Our results suggest that cysC measurement can be used to characterize glomerular function in children with cancer.