Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricus L3

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• 作者：Jie Zhang ; Lili Lu ; Li Lu ; Yang Zhao ; Liping Kang ; Xu Pang…
• 关键词：Steroidal saponins ; Galactosylation ; β ; galactosidase ; Lactobacillus bulgaricus L3
• 刊名：Glycoconjugate Journal
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：33
• 期：1
• 页码：53-62
• 全文大小：1,440 KB
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• 作者单位：Jie Zhang (1) (3)
  Lili Lu (2)
  Li Lu (1)
  Yang Zhao (1)
  Liping Kang (4)
  Xu Pang (1)
  Jingyuan Liu (1)
  Tengchuan Jiang (1)
  Min Xiao (2)
  Baiping Ma (1)
  
  1. Beijing Institute of Radiation Medicine, 27# Tai-ping Road, Haidian District, Beijing, 100850, China
  3. Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang, 065001, China
  2. State Key Lab of Microbial Technology and National Glycoengineering Research Center, Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, 27 Shanda South Road, Jinan, 250100, China
  4. State Key Laboratory of Dao-di Herbs, National Resource Center of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16# Nanxiaojie, Dongcheng District, Beijing, 100700, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-4986

文摘

The galactosylation of furostanosides and spirostanosides were investigated by using β-galactosidase from Lactobacillus bulgaricus L3 as a catalyst and lactose as a sugar donor. Four novel galactosylated furostanoside products (compounds 1–4) from compound F, compound G, compound I, and compound H were obtained and their structures were identified by HR-ESI-MS, 1D and 2D NMR spectra. The result showed that galactosyl moiety was found to be added to the 6-OH of the 26-O-glucosyl in these four furostanoside substrates. Keywords Steroidal saponins Galactosylation β-galactosidase Lactobacillus bulgaricus L3