Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients
详细信息 查看全文
- 作者：Aurélien Mary ; Agnes Hartemann ; Sophie Liabeuf…
- 关键词：Oral pharmacological agents ; Macrovascular disease ; Imaging (MRI/PET/other) ; Biological statistics ; Clinical science ; Human ; Clinical science and care (all)
- 刊名：Cardiovascular Diabetology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：16
- 期：1
- 全文大小：1119KB
- 刊物主题：Diabetes; Angiology; Cardiology;
- 出版者：BioMed Central
- ISSN：1475-2840
- 卷排序：16
文摘
BackgroundVascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. However, metformin’s effects in patients with diabetic VC have not previously been characterized. The present study investigated the association between metformin use and lower-limb arterial calcification in patients with type 2 diabetes and high cardiovascular risk.