Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls—a pilot study
详细信息 查看全文
- 作者：Erika Timby ; Torbjörn Bäckström ; Sigrid Nyberg ; Hans Stenlund…
- 刊名：Psychopharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：233
- 期：11
- 页码：2109-2117
- 全文大小：490 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Pharmacology and Toxicology
Psychiatry - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-2072
- 卷排序：233
文摘
RationaleIn premenstrual dysphoric disorder (PMDD), a condition that afflicts 3–8 % of women in fertile ages, the cyclic recurrence of debilitating mood symptoms is restricted to the luteal phase of the menstrual cycle. The progesterone metabolite allopregnanolone is produced by the corpus luteum, and circulating levels are reflected in the brain. Allopregnanolone is a modulator of the GABAA receptor, enhancing the effect of γ-aminobutyric acid (GABA). Previous studies have demonstrated different sensitivity to other GABAA receptor agonists, i.e., benzodiazepines, alcohol, and pregnanolone, in PMDD patients compared to controls.