Clinical significance of Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer

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• 作者：Heng Wei (1)
  Ning Wang (1)
  Yao Zhang (1)
  Shizhuo Wang (1)
  Xiaoao Pang (1)
  Jing Zhang (1)
  Qingshuang Luo (1)
  Youbo Su (2)
  Shulan Zhang (1)
  
• 关键词：Wnt ; 11 ; Squamous cell carcinoma antigen (SCC ; Ag) ; Cervical cancer ; Immunohistochemistry
• 刊名：Medical Oncology
• 出版年：2014
• 出版时间：May 2014
• 年：2014
• 卷：31
• 期：5
• 全文大小：508 KB
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• 作者单位：Heng Wei (1)
  Ning Wang (1)
  Yao Zhang (1)
  Shizhuo Wang (1)
  Xiaoao Pang (1)
  Jing Zhang (1)
  Qingshuang Luo (1)
  Youbo Su (2)
  Shulan Zhang (1)
  
  1. Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang, 110004, Liaoning Province, China
  2. Practical Pharmacy and Clinical Remedies, Shengjing Hospital, China Medical University, No. 36 Sanhao St, Heping District, Shenyang, 110004, Liaoning Province, China
  
• ISSN：1559-131X

文摘

The purpose of the study was to determine the expression patterns of Wnt-11 and squamous cell carcinoma antigen in cervical cancer tissues and to explore their clinical significance and correlation with clinicopathological parameters. The expression of Wnt-11 and squamous cell carcinoma antigen was detected in 127 cervical cancer tissues, 21 cervical intraepithelial neoplasia, as well as in 20 healthy controls by immunohistochemistry, and the relationship of Wnt-11 and squamous cell carcinoma antigen expression with clinicopathological parameters was analyzed. Both Wnt-11 and squamous cell carcinoma antigen were more commonly expressed in cervical cancer than in cervical intraepithelial neoplasia and in normal cervical tissue (respectively; P?<?0.05); further, Wnt-11 and squamous cell carcinoma antigen expression in cervical cancer were positively correlated (r?=?0.271, P?<?0.05). In comparing the expression with clinicopathological parameters of tumor samples, Wnt-11 and squamous cell carcinoma antigen were both associated with FIGO stage, lymph node metastasis, and tumor size (P?<?0.05), but not with patient age, pathological type, or differentiation. Increased Wnt-11 protein levels in cervical carcinoma samples were associated with a poor outcome in univariate and multivariate analysis. Wnt-11 and squamous cell carcinoma antigen are related to the malignancy degree and metastasis of cervical cancer, and thus may play a coordinating role in the occurrence and progression of cervical cancer. The study indicated that Wnt-11 may be a useful prognostic indicator for cervical carcinoma.