Control of meiotic recombination initiation: a role for the environment?

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• 作者：Amnon Koren ; Shay Ben-Aroya and Martin Kupiec
• 刊名：Current Genetics
• 出版年：2002
• 出版时间：December 2002
• 年：2002
• 卷：42
• 期：3
• 页码：129-139
• 全文大小：235 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Microbial Genetics and Genomics
  Microbiology
  Biochemistry
  Cell Biology
  Plant Sciences
  Proteomics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0983

文摘

Homologous recombination plays a central role during meiosis, ensuring the proper segregation of homologous chromosomes during the first meiotic division. In addition, meiotic recombination generates genetic variability upon which natural selection can act. The frequency of recombination is not evenly distributed throughout the genome: regions of high (hotspots) and low (coldspots) recombination can be found. Meiotic hotspots exhibit high levels of double-strand break formation and these breaks coincide with the upstream regions of genes. In many cases, binding of transcription factors has been shown to be required for hotspot activity. We review the current knowledge on the mechanisms that determine hotspot activity and propose a modified model to account for recent observations which show that recombination frequency at hotspots is sensitive to environmental conditions.