Does primary neoadjuvant systemic therapy eradicate minimal residual disease? Analysis of disseminated and circulating tumor cells before and after therapy
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- 作者：Sabine Kasimir-Bauer ; Ann-Kathrin Bittner ; Lisa König…
- 关键词：Breast cancer ; Circulating tumor cells ; Disseminated tumor cells ; Minimal residual disease neoadjuvant therapy ; Stem cells ; EMT
- 刊名：Breast Cancer Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：18
- 期：1
- 全文大小：1,283 KB
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Ann-Kathrin Bittner (1)
Lisa König (1)
Katharina Reiter (1)
Thomas Keller (2)
Rainer Kimmig (1)
Oliver Hoffmann (1)
1. Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany
2. ACOMED Statistik, Fockestrasse 57, D-04275, Leipzig, Germany - 刊物主题：Cancer Research; Oncology;
- 出版者：BioMed Central
- ISSN：1465-5411
文摘
Background Patients with breast cancer (BC) undergoing neoadjuvant chemotherapy (NACT) may experience metastatic relapse despite achieving a pathologic complete response. We analyzed patients with BC before and after NACT for disseminated tumor cells (DTCs) in the bone marrow(BM); comprehensively characterized circulating tumor cells (CTCs), including stem cell–like CTCs (slCTCs), in blood to prove the effectiveness of treatment on these cells; and correlated these findings with response to therapy, progression-free survival (PFS), and overall survival (OS).