Exonization of active mouse L1s: a driver of transcriptome evolution?

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• 作者：Tomasz Zemojtel (1)
  Tobias Penzkofer (2)
  J?rg Schultz (2)
  Thomas Dandekar (2)
  Richard Badge (3)
  Martin Vingron (1)
  
• 刊名：BMC Genomics
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：8
• 期：1
• 全文大小：1385KB
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• 作者单位：Tomasz Zemojtel (1)
  Tobias Penzkofer (2)
  J?rg Schultz (2)
  Thomas Dandekar (2)
  Richard Badge (3)
  Martin Vingron (1)
  
  1. Department of Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, D-14195, Berlin, Germany
  2. Department of Bioinformatics, University of Würzburg, D-97074, Am Hubland, Würzburg, Germany
  3. Department of Genetics, University of Leicester, University Road, LE1 7RH, Leicester, UK
  

文摘

Background Long interspersed nuclear elements (LINE-1s, L1s) have been recently implicated in the regulation of mammalian transcriptomes. Results Here, we show that members of the three active mouse L1 subfamilies (A, GF and TF) contain, in addition to those on their sense strands, conserved functional splice sites on their antisense strands, which trigger multiple exonization events. The latter is particularly intriguing in the light of the strong antisense orientation bias of intronic L1s, implying that the toleration of antisense insertions results in an increased potential for exonization. Conclusion In a genome-wide analysis, we have uncovered evidence suggesting that the mobility of the large number of retrotransposition-competent mouse L1s (~2400 potentially active L1s in NCBIm35) has significant potential to shape the mouse transcriptome by continuously generating insertions into transcriptional units.