Cardiorespiratory and neuromuscular deconditioning in fatigued and non-fatigued breast cancer survivors
详细信息 查看全文
- 作者：Sarah E. Neil (1) (2)
Riggs J. Klika (3)
S. Jayne Garland (1)
Donald C. McKenzie (4)
Kristin L. Campbell (1) - 关键词：Cancer ; Fatigue ; Physical activity ; Deconditioning ; Muscle
- 刊名：Supportive Care in Cancer
- 出版年：2013
- 出版时间：March 2013
- 年：2013
- 卷：21
- 期：3
- 页码：873-881
- 全文大小：223KB
- 参考文献：1. Hofman M, Ryan JL, Figueroa-Moseley CD, Jean-Pierre P, Morrow GR (2007) Cancer-related fatigue: the scale of the problem. Oncologist 12(Suppl 1):4-0 class="external" href="http://dx.doi.org/10.1634/theoncologist.12-S1-4">CrossRef
2. Holley S (2000) Cancer-related fatigue. Suffering a different fatigue. Cancer Pract 8(2):87-5 class="external" href="http://dx.doi.org/10.1046/j.1523-5394.2000.82007.x">CrossRef
3. Bower JE, Ganz PA, Desmond KA, Rowland JH, Meyerowitz BE, Belin TR (2000) Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life. J Clin Oncol 18(4):743-53
4. Dimeo FC (2001) Effects of exercise on cancer-related fatigue. Cancer 92(6 Suppl):1689-693 class="external" href="http://dx.doi.org/10.1002/1097-0142(20010915)92:6+<1689::AID-CNCR1498>3.0.CO;2-H">CrossRef
5. Geinitz H, Zimmermann FB, Thamm R, Keller M, Busch R, Molls M (2004) Fatigue in patients with adjuvant radiation therapy for breast cancer: long-term follow-up. J Cancer Res Clin Oncol 130(6):327-33. doi:class="a-plus-plus non-url-ref">10.1007/s00432-003-0540-9 class="external" href="http://dx.doi.org/10.1007/s00432-003-0540-9">CrossRef
6. Al-Majid S, McCarthy DO (2001) Cancer-induced fatigue and skeletal muscle wasting: the role of exercise. Biol Res Nurs 2(3):186-97 class="external" href="http://dx.doi.org/10.1177/109980040100200304">CrossRef
7. Morrow GR, Shelke AR, Roscoe JA, Hickok JT, Mustian K (2005) Management of cancer-related fatigue. Cancer Invest 23(3):229-39 class="external" href="http://dx.doi.org/10.1081/CNV-200055960">CrossRef
8. Jones LW, Eves ND, Haykowsky M, Freedland SJ, Mackey JR (2009) Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol 10(6):598-05. doi:class="a-plus-plus non-url-ref">10.1016/S1470-2045(09)70031-2 class="external" href="http://dx.doi.org/10.1016/S1470-2045(09)70031-2">CrossRef
9. Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard-Barbash R (2003) Physical activity levels before and after a diagnosis of breast carcinoma: the Health, Eating, Activity, and Lifestyle (HEAL) study. Cancer 97(7):1746-757. doi:class="a-plus-plus non-url-ref">10.1002/cncr.11227 class="external" href="http://dx.doi.org/10.1002/cncr.11227">CrossRef
10. Wasserman K (1987) Determinants and detection of anaerobic threshold and consequences of exercise above it. Circulation 76(6 Pt 2):VI29–VI39
11. Wasserman K, Beaver WL, Whipp BJ (1990) Gas exchange theory and the lactic acidosis (anaerobic) threshold. Circulation 81(1 Suppl):II14–II30
12. Faude O, Kindermann W, Meyer T (2009) Lactate threshold concepts: how valid are they? Sports Med (Auckland, NZ) 39(6):469-90 class="external" href="http://dx.doi.org/10.2165/00007256-200939060-00003">CrossRef
13. Peterson BMR, Chris P, Dallow K, Hayward R, Schneider CM (2011) Cancer-related fatigue and the impact of psychological and physiological variables. Med Sci Sports Exerc 43(5):562
14. Yavuzsen T, Davis MP, Ranganathan VK, Walsh D, Siemionow V, Kirkova J, Khoshknabi D, Lagman R, LeGrand S, Yue GH (2009) Cancer-related fatigue: central or peripheral? J Pain Symptom Manage 38(4):587-96. doi:class="a-plus-plus non-url-ref">10.1016/j.jpainsymman.2008.12.003 class="external" href="http://dx.doi.org/10.1016/j.jpainsymman.2008.12.003">CrossRef
15. Monga U, Jaweed M, Kerrigan AJ, Lawhon L, Johnson J, Vallbona C, Monga TN (1997) Neuromuscular fatigue in prostate cancer patients undergoing radiation therapy. Arch Phys Med Rehabil 78(9):961-66 class="external" href="http://dx.doi.org/10.1016/S0003-9993(97)90058-7">CrossRef
16. Gandevia SC (2001) Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81(4):1725-789
17. Enoka RM, Duchateau J (2008) Muscle fatigue: what, why and how it influences muscle function. J Physiol 586(1):11-3. doi:class="a-plus-plus non-url-ref">10.1113/jphysiol.2007.139477 class="external" href="http://dx.doi.org/10.1113/jphysiol.2007.139477">CrossRef
18. Evans WJ, Lambert CP (2007) Physiological basis of fatigue. Am J Phys Med Rehabil 86(1 Suppl):S29–S46 class="external" href="http://dx.doi.org/10.1097/PHM.0b013e31802ba53c">CrossRef
19. Cella D, Davis K, Breitbart W, Curt G (2001) Cancer-related fatigue: prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. J Clin Oncol 19(14):3385-391
20. Schneider J, Dudziak R, Westphal K, Vettermann J (1997) The i-STAT analyzer. A new, hand-held device for the bedside determination of hematocrit, blood gases, and electrolytes. Anaesthesist 46(8):704-14 class="external" href="http://dx.doi.org/10.1007/s001010050457">CrossRef
21. Patel KV (2008) Epidemiology of anemia in older adults. Semin Hematol 45(4):210-17. doi:class="a-plus-plus non-url-ref">10.1053/j.seminhematol.2008.06.006 class="external" href="http://dx.doi.org/10.1053/j.seminhematol.2008.06.006">CrossRef
22. Tanner RK, Fuller KL, Ross ML (2010) Evaluation of three portable blood lactate analysers: lactate pro, lactate scout and lactate plus. Eur J Appl Physiol 109(3):551-59. doi:class="a-plus-plus non-url-ref">10.1007/s00421-010-1379-9 class="external" href="http://dx.doi.org/10.1007/s00421-010-1379-9">CrossRef
23. Klika RJ, Golik KS, Drum SN, Callahan KE, Thorland WG (2011) Comparison of physiological response to cardiopulmonary exercise testing among cancer survivors and healthy controls. Eur J Appl Physiol 111(6):1167-176. doi:class="a-plus-plus non-url-ref">10.1007/s00421-010-1749-3 class="external" href="http://dx.doi.org/10.1007/s00421-010-1749-3">CrossRef
24. American College of Sports M (2009) ACSM's guidelines for exercise testing and prescription, vol 8. Lippincott, Williams and Wilkins, Philadelphia, pp 91-34
25. Coyle EF, Martin WH, Ehsani AA, Hagberg JM, Bloomfield SA, Sinacore DR, Holloszy JO (1983) Blood lactate threshold in some well-trained ischemic heart disease patients. J Appl Physiol Respir Environ Exerc Physiol 54(1):18-3
26. Brady MJ, Cella DF, Mo F, Bonomi AE, Tulsky DS, Lloyd SR, Deasy S, Cobleigh M, Shiomoto G (1997) Reliability and validity of the Functional Assessment of Cancer Therapy-Breast quality-of-life instrument. J Clin Oncol 15(3):974-86
27. Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E (1997) Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage 13(2):63-4 class="external" href="http://dx.doi.org/10.1016/S0885-3924(96)00274-6">CrossRef
28. Beck AT, Steer RA (1984) Internal consistencies of the original and revised Beck Depression Inventory. J Clin Psychol 40(6):1365-367 class="external" href="http://dx.doi.org/10.1002/1097-4679(198411)40:6<1365::AID-JCLP2270400615>3.0.CO;2-D">CrossRef
29. Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G (1978) A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 31(12):741-55 class="external" href="http://dx.doi.org/10.1016/0021-9681(78)90058-9">CrossRef
30. Drouin JS, Young TJ, Beeler J, Byrne K, Birk TJ, Hryniuk WM, Hryniuk LE (2006) Random control clinical trial on the effects of aerobic exercise training on erythrocyte levels during radiation treatment for breast cancer. Cancer 107(10):2490-495. doi:class="a-plus-plus non-url-ref">10.1002/cncr.22267 class="external" href="http://dx.doi.org/10.1002/cncr.22267">CrossRef
31. Dimeo F, Schwartz S, Wesel N, Voigt A, Thiel E (2008) Effects of an endurance and resistance exercise program on persistent cancer-related fatigue after treatment. Ann Oncol 19(8):1495-499. doi:class="a-plus-plus non-url-ref">10.1093/annonc/mdn068 class="external" href="http://dx.doi.org/10.1093/annonc/mdn068">CrossRef
32. Lane RJ, Barrett MC, Woodrow D, Moss J, Fletcher R, Archard LC (1998) Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 64(3):362-67 class="external" href="http://dx.doi.org/10.1136/jnnp.64.3.362">CrossRef
33. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett DR Jr, Schmitz KH, Emplaincourt PO, Jacobs DR Jr, Leon AS (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32(9 Suppl):S498–S504
34. Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH (2010) An update of controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. J Cancer Surviv 4(2):87-00. doi:class="a-plus-plus non-url-ref">10.1007/s11764-009-0110-5 class="external" href="http://dx.doi.org/10.1007/s11764-009-0110-5">CrossRef
35. Hurley MV, Rees J, Newham DJ (1998) Quadriceps function, proprioceptive acuity and functional performance in healthy young, middle-aged and elderly subjects. Age Ageing 27(1):55-2 class="external" href="http://dx.doi.org/10.1093/ageing/27.1.55">CrossRef
36. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen VE, Schwartz AL (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42(7):1409-426. doi:class="a-plus-plus non-url-ref">10.1249/MSS.0b013e3181e0c112 class="external" href="http://dx.doi.org/10.1249/MSS.0b013e3181e0c112">CrossRef - 作者单位：Sarah E. Neil (1) (2)
Riggs J. Klika (3)
S. Jayne Garland (1)
Donald C. McKenzie (4)
Kristin L. Campbell (1)
1. Department of Physical Therapy, University of British Columbia, 212-2177 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3
2. School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, Canada, V6T 1Z3
3. Cancer Survivor Center, 1450 Crystal Lake Road, Aspen, CO, 81611, USA
4. School of Kinesiology, University of British Columbia, 210-6081 University Blvd, Vancouver, BC, Canada, V6T 1Z1 - ISSN：1433-7339
文摘
Purpose Fatigue is one of the most commonly reported side effects during treatment for breast cancer and can persist following treatment completion. Cancer-related fatigue after treatment is multifactorial in nature, and one hypothesized mechanism is cardiorespiratory and neuromuscular deconditioning. The purpose of this study was to compare cardiorespiratory and neuromuscular function in breast cancer survivors who had completed treatment and met the specified criteria for cancer-related fatigue and a control group of breast cancer survivors without fatigue. Methods Participants in the fatigue (n--6) and control group (n--1) performed a maximal exercise test on a cycle ergometer for determination of peak power, power at lactate threshold, and VO2 peak. Neuromuscular fatigue was induced with a sustained submaximal contraction of the right quadriceps. Central fatigue (failure of voluntary activation) was evaluated using twitch interpolation, and peripheral fatigue was measured with an electrically evoked twitch. Results Power at lactate threshold was lower in the fatigue group (p--.05). There were no differences between groups for power at lactate threshold as percentage of peak power (p--.10) or absolute or relative VO2 peak (p--.08 and 0.33, respectively). When adjusted for age, the fatigue group had a lower power at lactate threshold (p--.02) and absolute VO2 peak (p--.03). There were no differences between groups in change in any neuromuscular parameters after the muscle-fatiguing protocol. Conclusions Findings support the hypothesis that cardiorespiratory deconditioning may play a role in the development and persistence of cancer-related fatigue following treatment. Future research into the use of exercise training to reduce cardiorespiratory deconditioning as a treatment for cancer-related fatigue is warranted to confirm these preliminary findings.