Decreased Susceptibility to Nitroimidazoles Among Bacteroides Species in Brazil
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- 作者：Jessica Manya B. D. Vieira ; Renata F. Boente ; Karla Rodrigues Miranda ; Kátia E. S. Avelar ; Regina M. C. P. Domingues and Maria Candida de S. Ferreira
- 刊名：Current Microbiology
- 出版年：2006
- 出版时间：January 2006
- 年：2006
- 卷：52
- 期：1
- 页码：27-32
- 全文大小：315 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Microbiology
Biotechnology - 出版者：Springer New York
- ISSN：1432-0991
文摘
In this study, 197 strains of Bacteroides genus from different species and origins were evaluated with regard to their susceptibility to 5-nitroimidazoles (5-Ni)—such as tinidazole, ornidazole, and metronidazole—using the agar dilution method. The presence of nim genes was also investigated by polymerase chain reaction. It was found that 5.6% of Bacteroides strains among all origins showed decreased susceptibility (minimum inhibitory concentrations varying from 4 to 16 μg/ml) to at least one of the imidazoles studied without any known nim gene associate. Also, we detected one strain isolated from a polluted aquatic environment in which one nim gene was found and characterized as nim B using restriction fragment length polymorphism and sequencing. Hence, resistance to 5-Ni should be monitored closely because they constitute, among few drugs, the ones quite effective in treating Bacteroides infections.