Acute hepatitis C: clinical and laboratory diagnosis, course of the disease, treatment
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- 作者：E. Sagnelli (1)
T. Santantonio (2)
N. Coppola (1)
M. Fasano (2)
M. Pisaturo (1)
C. Sagnelli (3) - 关键词：Acute hepatitis C ; Acute viral hepatitis ; Treatment acute hepatitis C ; Diagnosis acute hepatitis C
- 刊名：Infection
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：42
- 期：4
- 页码：601-610
- 全文大小：371 KB
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T. Santantonio (2)
N. Coppola (1)
M. Fasano (2)
M. Pisaturo (1)
C. Sagnelli (3)
1. Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, via L. Armanni, No. 3, 80135, Naples, Italy
2. Department of Clinical and Experimental Medicine, Clinic of Infectious Diseases, University of Foggia, Foggia, Italy
3. Department of Experimental Medicine and Surgery “F. Magrassi e A. Lanzara- Second University of Naples, Naples, Italy - ISSN：1439-0973
文摘
Introduction Acute hepatitis C (AHC) is asymptomatic in about 70-0 % of cases and, therefore, is usually undiagnosed. Although the clinical course is typically mild, AHC has a high rate of transition to chronicity. Material and methods We evaluated the literature data concerning risk factors for HCV transmission, diagnosis, natural history, and antiviral treatment of AHC. Results Although new methods have been developed, anti-HCV seroconversion remains the gold standard for the diagnosis of AHC. This phenomenon, however, is identifiable in less than half of cases in the everyday clinical practice, since most AHC patients do not know their previous anti-HCV/HCV-RNA status. An early short-term interferon treatment in AHC patients prevents progression to chronicity in most of treated patients. Conclusion The literature data give evidence of the clinical relevance of an early diagnosis of AHC for an early short-term interferon treatment. There is also the suggestion to use newly developed laboratory methods to distinguish AHC from an acute exacerbation of a chronic HCV infection.