Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

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• 作者：Daimei Sasayama (1) (2)
  Hiroaki Hori (1) (3)
  Toshiya Teraishi (1)
  Kotaro Hattori (1)
  Miho Ota (1)
  Yoshimi Iijima (4)
  Masahiko Tatsumi (5)
  Teruhiko Higuchi (6)
  Naoji Amano (2)
  Hiroshi Kunugi (1) (3)
  
• 刊名：Behavioral and Brain Functions
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：7
• 期：1
• 全文大小：220KB
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• 作者单位：Daimei Sasayama (1) (2)
  Hiroaki Hori (1) (3)
  Toshiya Teraishi (1)
  Kotaro Hattori (1)
  Miho Ota (1)
  Yoshimi Iijima (4)
  Masahiko Tatsumi (5)
  Teruhiko Higuchi (6)
  Naoji Amano (2)
  Hiroshi Kunugi (1) (3)
  
  1. Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan
  2. Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, 390-8621, Japan
  3. Core Research of Evolutional Science & Technology (CREST), Japan Science and Technology Agency (JST), Tokyo, 102-0075, Japan
  4. Department of Medical Genetics, Majors of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, 305-8577, Japan
  5. Yokohama Shinryo Clinic, Yokohama, 221-0835, Japan
  6. National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan
  
• ISSN：1744-9081

文摘

Background Several lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1β) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms. Methods A total of 533 patients with schizophrenia (302 males: mean age ± standard deviation 43.4 ± 13.0 years; 233 females; mean age 44.8 ± 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 ± 17.3 years; 748 females; 46.3 ± 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1β gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia. Results Significant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032). Conclusions The present study shows the first evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1β gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1β in the etiology of schizophrenia.