Knee extensor muscle strength and index of renal function associated with an exercise capacity of 5 metabolic equivalents in male chronic heart failure patients with chronic kidney disease

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• 作者：Chiharu Hotta (1)
  Koji Hiraki (2)
  Satoshi Watanabe (2)
  Kazuhiro P. Izawa (2)
  Takashi Yasuda (3)
  Naohiko Osada (4)
  Kazuto Omiya (4)
  Kenjiro Kimura (3)
  
• 关键词：Exercise capacity ; Chronic heart failure ; Chronic kidney disease ; Knee extensor muscle strength
• 刊名：Clinical and Experimental Nephrology
• 出版年：2014
• 出版时间：April 2014
• 年：2014
• 卷：18
• 期：2
• 页码：313-319
• 全文大小：367 KB
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• 作者单位：Chiharu Hotta (1)
  Koji Hiraki (2)
  Satoshi Watanabe (2)
  Kazuhiro P. Izawa (2)
  Takashi Yasuda (3)
  Naohiko Osada (4)
  Kazuto Omiya (4)
  Kenjiro Kimura (3)
  
  1. Department of Rehabilitation Medicine, Kawasaki Municipal Tama Hospital, Kawasaki, Kanagawa, Japan
  2. Department of Rehabilitation Medicine, St. Marianna University School of Medicine Hospital, 2-16-1 Sugao, Miyamaeku, Kawasaki, Kanagawa, 216-8511, Japan
  3. Division of Nephrology and Hypertension, Department of Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
  4. Division of Cardiology, Department of Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan
  
• ISSN：1437-7799

文摘

Background The goal of the present study was to determine knee extensor muscle strength (KEMS) and degree of renal dysfunction associated with an exercise capacity of ? metabolic equivalents (METs) in male chronic heart failure (CHF) patients with chronic kidney disease (CKD). Methods In this cross-sectional study of 75 male CHF patients with CKD (65.3?±?11.6?years), we measured clinical characteristics, peak $ \dot{V}{\text{O}}_{2} $ , estimated glomerular filtration rate (eGFR), and KEMS. Patients were divided into two groups by exercise capacity: ? METs group (n?=?41) and <5 METs group (n?=?34). Cutoff values for KEMS and eGFR resulting in an exercise capacity of ? METs were selected with ROC curves. Patients were divided into four groups according to cutoff values, and numbers of patients attaining an exercise capacity of ? METs were compared between groups. Results Age was significantly higher although eGFR, Hb, and KEMS were lower in the <5 METs versus ? METs group (P?<?0.001). Multiple logistic regression analysis revealed a positive significant relation between KEMS and eGFR and exercise capacity of ? METs. Exercise capacity of ? METs was associated with KEMS of approximately 1.69?Nm/kg and an eGFR of 45.7?mL/min/1.73?m2. The number of patients attaining an exercise capacity of ? METs in the patients who did not reach both cutoff values was significantly lower than that in any other patients (P?<?0.001). Conclusion KEMS and eGFR may be useful indices for predicting attainment of exercise capacity of ? METs in male CHF patients with CKD.