Hair analysis of drugs involved in drug-facilitated sexual assault and detection of zolpidem in a suspected case

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• 作者：Alberto Salomone (1) alberto.salomone@antidoping.piemonte.it
  Enrico Gerace (1)
  Daniele Di Corcia (1)
  Gianmario Martra (2)
  Michele Petrarulo (13)
  Marco Vincenti (14)
• 关键词：Rape drugs – ; Hair analysis – ; Zolpidem – ; Keratin structure
• 刊名：International Journal of Legal Medicine
• 出版年：2012
• 出版时间：May 2012
• 年：2012
• 卷：126
• 期：3
• 页码：451-459
• 全文大小：366.3 KB
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• 作者单位：1. Centro Regionale Antidoping 鈥淎. Bertinaria鈥? Regione Gonzole, 10/1, 10043 Orbassano, Turin, Italy2. Dipartimento di Chimica Inorganica, Fisica e dei Materiali, Universit脿 degli Studi di Torino, via P. Giuria 7, 10125 Turin, Italy3. A.O. Ordine Mauriziano, Largo F. Turati 62, 10128 Turin, Italy4. Dipartimento di Chimica Analitica, Universit脿 degli Studi di Torino, via P. Giuria 5, 10125 Turin, Italy
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Forensic Medicine
  Medical Law
  Medicine/Public Health, general
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1437-1596

文摘

In drug-facilitated crimes, victims are subjected to nonconsensual acts while they are incapacitated by the effects of a drug. A specific LC-MS/MS protocol for determining benzodiazepines and hypnotics at low concentration in hair specimens was developed and validated in order to target the allegedly administered drugs on a chronological basis. In the case hereby reported, a 26-year-old woman claimed to have been sexually assaulted after being administered an allegedly drugged coffee, but toxicological analysis of urine and blood provided no evidence of any drug intake. Subsequently, a second woman accused the same man of sexual abuse. Hence, the suspect was prosecuted. Specimens were collected from four subjects (two alleged victims, the suspect and his wife) and segmental hair analysis was performed. The results revealed that zolpidem was present at low picogram per milligram concentration in three out of eleven segments of hair specimen obtained from the first of the alleged victims, offering plain evidence of single or sporadic exposure, whereas the agent was detected in the high picogram per milligram range in the hair collected from suspect’s wife, coherently with therapeutic administration. The presence of interfering signals typical of the keratin-containing matrix was found and possible hair degradation by cosmetic treatments was investigated by electron microscopy, so as to obtain a judicious interpretation of the analytical findings.