Development of Multi-Phase Emulsions Based on Bioresorbable Polymers and Oily Adjuvant
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- 作者：Ming-Hsi Huang ; Chiung-Yi Huang ; Shu-Pei Lien ; Syuan-Yi Siao ; Ai-Hsiang Chou ; Hsin-Wei Chen ; Shih-Jen Liu ; Chih-Hsiang Leng and Pele Chong
- 关键词：KEY WORDS bioresorbable polymer ; immune response ; multi ; phase emulsion ; polymeric emulsifier ; vaccine adjuvant
- 刊名：Pharmaceutical Research
- 出版年：2009
- 出版时间：August, 2009
- 年：2009
- 卷：26
- 期：8
- 页码：1856-1862
- 全文大小：267.4 KB
文摘
Purpose To enhance the water affinity of W/O emulsion-adjuvanted vaccines, we used three bioresorbable polymers named PEG-b-PLA, PEG-b-PCL, and PEG-b-PLACL as hydrophilic emulsifier to stabilize the interfaces between the oily Montanide ISA 51 adjuvant and the antigen media.