Nanomechanical Motion of Microcantilevers Driven by Ion-Induced DNA Conformational Transitions

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• 作者：Kilho Eom (1) (2)
  Huihun Jung (3)
  Suho Jeong (3)
  Chi Hyun Kim (3)
  Dae Sung Yoon (1) (3)
  Taeyun Kwon (1) (3)
  
• 关键词：Microcantilever ; DNA motor ; Conformational change ; Ion sensing ; Bending deflection motion
• 刊名：BioNanoScience
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：1
• 期：4
• 页码：117-122
• 全文大小：307KB
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• 作者单位：Kilho Eom (1) (2)
  Huihun Jung (3)
  Suho Jeong (3)
  Chi Hyun Kim (3)
  Dae Sung Yoon (1) (3)
  Taeyun Kwon (1) (3)
  
  1. Institute for Molecular Sciences, Seoul, 120-752, Republic of Korea
  2. Department of Mechanical Engineering, Korea University, Seoul, 136-701, Republic of Korea
  3. Department of Biomedical Engineering, Yonsei University, Wonju, 220-740, Republic of Korea
  
• ISSN：2191-1649

文摘

In this paper, we report the nanomechanical motion of a microcantilever due to the conformational transitions of DNA molecules that are functionalized on the surface of a microcantilever. In particular, the conformational transitions of DNA molecules can be induced by the change of ionic concentrations, which results in the bending deflection motion of a microcantilever. It is shown that a cantilever-DNA hybrid system is able to sense and detect the chemical environment changes such as pH change and/or ionic concentration change, and also that microscale device such as microcantilever can be actuated using molecular conformational changes. Our study provides a new insight into the development of a novel nano-bio-hybrid system based on microdevice coupled with molecular motors for chemical sensing as well as chemical-driven actuation.