The effects of diabetes medications on post-operative long bone fracture healing

详细信息    查看全文

• 作者：C. Simpson ; D. Jayaramaraju ; D. Agraharam…
• 关键词：Diabetes ; Fracture (+/鈭?healing) ; Osteogenesis ; Insulin ; Biguanide ; Sulphonylurea
• 刊名：European Journal of Orthopaedic Surgery & Traumatology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：25
• 期：8
• 页码：1239-1243
• 全文大小：397 KB
• 参考文献：1. NHS (2011) Diabetic prevelence. NHS England, UK
  2.NHS (2011) NHS hospital episode statistics. NHS England, UK
  3.Cozen L (1972) Does diabetes delay fracture healing? Clin Orthop Relat Res 82:134鈥?40PubMed
  4.Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res 232:210PubMed
  5.Bouillon R (1991) Diabetic bone disease. Calcif Tissue Int 49(3):155鈥?60CrossRef PubMed
  6.Simpson CM, Calori GM, Giannoudis PV (2012) Diabetes and fracture healing: the skeletal effects of diabetic drugs. Expert Opin Drug Saf 11(2):215鈥?20CrossRef PubMed
  7.Beam HA, Parsons JR, Lin SS (2006) The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthop Res 20(6):1210鈥?216CrossRef
  8.Follak N, Kl枚ting I, Wolf E, Merk H (2004) Improving metabolic control reverses the histomorphometric and biomechanical abnormalities of an experimentally induced bone defect in spontaneously diabetic rats. Calcif Tissue Int 74(6):551鈥?60CrossRef PubMed
  9.Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC (2003) A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes 52(6):1502鈥?510CrossRef PubMed
  10.Kayal RA, Alblowi J, McKenzie E, Krothapalli N, Silkam L, Gerstenfeld L et al (2009) Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone 44(2):357鈥?63PubMedCentral CrossRef PubMed
  11.Yamagishi S, Nakamura K, Inoue H (2005) Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients. Med Hypotheses 65(6):1013CrossRef PubMed
  12.Cortizo AM, Sedlinsky C, McCarthy AD, Blanco A, Shurman L (2006) Osteogenic actions of the anti-diabetic drug metformin on osteoblasts in culture. Eur J Pharmacol 536(1):38鈥?6CrossRef PubMed
  13.Kanazawa I, Yamaguchi T, Yano S, Yamauchi M, Sugimoto T (2008) Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression. Biochem Biophys Res Commun 375(3):414鈥?19CrossRef PubMed
  14.Molinuevo MS, Schurman L, McCarthy AD, Cortizo AM, Tolosa MJ, Gangoiti MV (2010) Effect of metformin on bone marrow progenitor cell differentiation: in vivo and in vitro studies. J Bone Miner Res 25(2):211鈥?21CrossRef PubMed
  15.Gao Y, Li Y, Xue J, Jia Y, Hu J (2010) Effect of the anti-diabetic drug metformin on bone mass in ovariectomized rats. Eur J Pharmacol 635(1):231鈥?36CrossRef PubMed
  16.Saito M, Fujii K, Moti Y, Marumo K (2006) Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats. Osteoporos Int 17(10):1514鈥?523CrossRef PubMed
  17.Shockley KR, Rosen CJ, Churchill GA, Lecka-Czernik B (2008) PPAR纬2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem 106(2):232鈥?46CrossRef
  18.Lin TH, Yang RS, Tang CH, Lin CP, Fu WM (2007) PPAR纬 inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats. Bone 41(4):562鈥?74CrossRef PubMed
  19.Grey A, Bolland M, Gamble G, Wattie D, Horne A, Davisdon J, Reid IR (2007) The peroxisome proliferator-activated receptor-纬 agonist rosiglitazone decreases bone formation and bone mineral density in healthy postmenopausal women: a randomized, controlled trial. J Clin Endocrinol Metab 92(4):1305鈥?310CrossRef PubMed
  20.Lecka-Czernik B (2010) Bone loss in diabetes: use of antidiabetic thiazolidinediones and secondary osteoporosis. Curr Osteoporos Rep 8(4):178鈥?84PubMedCentral CrossRef PubMed
  21.Kyle KA, Willett TL, Baggio LL, Drucker DJ, Grynpas MD (2011) Differential effects of PPAR-纬 activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice. Endocrinology 152(2):457鈥?67PubMedCentral CrossRef PubMed
  
• 作者单位：C. Simpson (1) (4)
  D. Jayaramaraju (2)
  D. Agraharam (2)
  S. Gudipati (1)
  R. Shanmuganathan (2)
  P. V. Giannoudis (1) (3)
  
  1. Academic Department of Trauma and Orthopaedics, Leeds General Infirmary, Great George Street, Leeds, England, UK
  4. 35 Potters Lane, East Leake, Loughborough, LE12 6NQ, England, UK
  2. Academic Department of Trauma and Orthopaedics, Ganga Medical Centre and Hospitals, Coimbatore, India
  3. Leeds Biomedical Research Unit, Chappell Allerton Hospital, Leeds, England, UK
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgical Orthopedics
  Traumatic Surgery
  
• 出版者：Springer Paris
• ISSN：1432-1068

文摘

Purpose Diabetes has long been known to have an impact on bone repair. More recently, however, most diabetic patients receive medications to normalise this hyperglycaemic environment. To date, no studies have investigated the effects of diabetic medications on fracture healing in humans.