Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle

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• 作者：Taylor K. Soderborg ; Sarah J. Borengasser ; Linda A. Barbour…
• 关键词：Diabetes ; Infant ; Maternal ; Microbiome ; Obesity ; Pregnancy ; Review
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：59
• 期：5
• 页码：895-906
• 全文大小：535 KB
• 参考文献：1.Heerwagen MJ, Miller MR, Barbour LA, Friedman JE (2010) Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol 299:R711–R722CrossRef PubMed PubMedCentral
  2.Nolan CJ (2013) Normal long-term health for infants of diabetic mothers: can we achieve it? J Clin Endocrinol Metab 98:3592–3594CrossRef PubMed
  3.Friedman JE (2015) Obesity and gestational diabetes mellitus pathways for programming in mouse, monkey, and man—where do we go next? The 2014 Norbert Freinkel Award Lecture. Diabetes Care 38:1402–1411CrossRef PubMed
  4.Barbour LA (2014) Changing perspectives in pre-existing diabetes and obesity in pregnancy: maternal and infant short- and long-term outcomes. Curr Opin Endocrinol Diabetes Obes 21:257–263CrossRef PubMed
  5.Weng SF, Redsell SA, Nathan D, Swift JA, Yang M, Glazebrook C (2013) Estimating overweight risk in childhood from predictors during infancy. Pediatrics 132:e414–e421CrossRef PubMed
  6.Boney CM, Verma A, Tucker R, Vohr BR (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115:e290–e296CrossRef PubMed
  7.McCurdy CE, Bishop JM, Williams SM et al (2009) Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 119:323–335PubMed PubMedCentral
  8.Thorn SR, Baquero KC, Newsom SA et al (2014) Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates. Diabetes 63:2702–2713CrossRef PubMed PubMedCentral
  9.Brumbaugh DE, Tearse P, Cree-Green M et al (2013) Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr 162:930–936CrossRef PubMed PubMedCentral
  10.Brumbaugh DE, Friedman JE (2014) Developmental origins of nonalcoholic fatty liver disease. Pediatr Res 75:140–147CrossRef PubMed PubMedCentral
  11.Sullivan EL, Nousen EK, Chamlou KA, Grove KL (2012) The impact of maternal high-fat diet consumption on neural development and behavior of offspring. Int J Obes Suppl 2:S7–S13CrossRef PubMed PubMedCentral
  12.Boyle KE, Patinkin ZW, Shapiro ALB, Baker PR II, Dabelea D, Friedman JE (2015) Mesenchymal stem cells from infants born to obese mothers exhibit greater potential for adipogenesis: the Healthy Start BabyBUMP Project. Diabetes. doi:10.​2337/​db15-0849
  13.Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031CrossRef PubMed
  14.Ridaura VK, Faith JJ, Rey FE et al (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214CrossRef PubMed
  15.Koleva PT, Bridgman SL, Kozyrskyj AL (2015) The infant gut microbiome: evidence for obesity risk and dietary intervention. Nutrients 7:2237–2260CrossRef PubMed PubMedCentral
  16.Ma J, Prince AL, Bader D et al (2014) High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model. Nat Commun 5:3889PubMed PubMedCentral
  17.Mirpuri J, Raetz M, Sturge CR et al (2014) Proteobacteria-specific IgA regulates maturation of the intestinal microbiota. Gut Microbes 5:28–39CrossRef PubMed PubMedCentral
  18.Eggesbø M, Moen B, Peddada S et al (2011) Development of gut microbiota in infants not exposed to medical interventions. APMIS 119:17–35CrossRef PubMed PubMedCentral
  19.Koenig JE, Spor A, Scalfone N et al (2011) Succession of microbial consortia in the developing infant gut microbiome. Proc Natl Acad Sci U S A 108:4578–4585CrossRef PubMed PubMedCentral
  20.Bäckhed F, Roswall J, Peng Y et al (2015) Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 17:690–703CrossRef PubMed
  21.Santacruz A, Collado MC, García-Valdés L et al (2010) Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. Br J Nutr 104:83–92CrossRef PubMed
  22.Collado MC, Isolauri E, Laitinen K, Salminen S (2008) Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women. Am J Clin Nutr 88:894–899PubMed
  23.Basu S, Haghiac M, Surace P et al (2011) Pregravid obesity associates with increased maternal endotoxemia and metabolic inflammation. Obesity 19:476–482CrossRef PubMed PubMedCentral
  24.Koren O, Goodrich JK, Cullender TC et al (2012) Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150:470–480CrossRef PubMed PubMedCentral
  25.DiGiulio DB, Callahan BJ, McMurdie PJ et al (2015) Temporal and spatial variation of the human microbiota during pregnancy. Proc Natl Acad Sci U S A 112:11060–11065CrossRef PubMed PubMedCentral
  26.Dominguez-Bello MG, Costello EK, Contreras M et al (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A 107:11971–11975CrossRef PubMed PubMedCentral
  27.Dogra S, Sakwinska O, Soh SE et al (2015) Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. MBio 6, e02419CrossRef PubMed PubMedCentral
  28.Azad MB, Konya T, Maughan H et al (2013) Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months. CMAJ 185:385–394CrossRef PubMed PubMedCentral
  29.Mueller NT, Whyatt R, Hoepner L et al (2015) Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. Int J Obes (Lond) 39:665–670CrossRef
  30.Cardwell CR, Stene LC, Joner G et al (2008) Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia 51:726–735CrossRef PubMed
  31.Hu J, Nomura Y, Bashir A et al (2013) Diversified microbiota of meconium is affected by maternal diabetes status. PLoS One 8, e78257CrossRef PubMed PubMedCentral
  32.Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J (2014) The placenta harbors a unique microbiome. Sci Transl Med 6:237ra265
  33.Savino F, Benetti S, Liguori SA, Sorrenti M, Cordero Di Montezemolo L (2013) Advances on human milk hormones and protection against obesity. Cell Mol Biol 59:89–98PubMed
  34.Yan J, Liu L, Zhu Y, Huang G, Wang PP (2014) The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health 14:1267CrossRef PubMed PubMedCentral
  35.Young BE, Johnson SL, Krebs NF (2012) Biological determinants linking infant weight gain and child obesity: current knowledge and future directions. Adv Nutr 3:675–686CrossRef PubMed PubMedCentral
  36.Woo JG, Martin LJ (2015) Does breastfeeding protect against childhood obesity? Moving beyond observational evidence. Curr Obes Rep 4:207–216CrossRef PubMed
  37.Oben JA, Mouralidarane A, Samuelsson AM et al (2010) Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 52:913–920CrossRef PubMed
  38.Myles IA, Fontecilla NM, Janelsins BM, Vithayathil PJ, Segre JA, Datta SK (2013) Parental dietary fat intake alters offspring microbiome and immunity. J Immunol 191:3200–3209CrossRef PubMed
  39.Zivkovic AM, German JB, Lebrilla CB, Mills DA (2011) Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci U S A 108:4653–4658CrossRef PubMed PubMedCentral
  40.Bode L (2009) Human milk oligosaccharides: prebiotics and beyond. Nutr Rev 67:S183–S191CrossRef PubMed
  41.Wacklin P, Mäkivuokko H, Alakulppi N et al (2011) Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine. PLoS One 6, e20113CrossRef PubMed PubMedCentral
  42.Martin R, Jimenez E, Heilig H et al (2009) Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR. Appl Environ Microbiol 75:965–969CrossRef PubMed PubMedCentral
  43.Hunt KM, Foster JA, Forney LJ et al (2011) Characterization of the diversity and temporal stability of bacterial communities in human milk. PLoS One 6, e21313CrossRef PubMed PubMedCentral
  44.Cabrera-Rubio R, Collado MC, Laitinen K, Salminen S, Isolauri E, Mira A (2012) The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J Clin Nutr 96:544–551CrossRef PubMed
  45.Young BE, Morrow A, Davidson B, Geraghty S, Patinkin ZW, Krebs NF (2014) 4-Hydroxynonenol is present in human milk and related to gestational age at delivery and excessive infant weight gain. FASEB J 28:247.246CrossRef
  46.Fields DA, Demerath EW (2012) Relationship of insulin, glucose, leptin, IL-6 and TNF-alpha in human breast milk with infant growth and body composition. Pediatr Obes 7:304–312CrossRef PubMed PubMedCentral
  47.Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T (1987) Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother 31:27–31CrossRef PubMed PubMedCentral
  48.Matias SL, Dewey KG, Quesenberry CP Jr, Gunderson EP (2014) Maternal prepregnancy obesity and insulin treatment during pregnancy are independently associated with delayed lactogenesis in women with recent gestational diabetes mellitus. Am J Clin Nutr 99:115–121CrossRef PubMed PubMedCentral
  49.Stuebe AM (2015) Does breastfeeding prevent the metabolic syndrome, or does the metabolic syndrome prevent breastfeeding? Semin Perinatol 39:290–295CrossRef PubMed
  50.Roger LC, Costabile A, Holland DT, Hoyles L, McCartney AL (2010) Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life. Microbiology 156:3329–3341CrossRef PubMed
  51.Bailey LC, Forrest CB, Zhang P, Richards TM, Livshits A, DeRusso PA (2014) Association of antibiotics in infancy with early childhood obesity. JAMA Pediatr 168:1063–1069CrossRef PubMed
  52.Azad MB, Bridgman SL, Becker AB, Kozyrskyj AL (2014) Infant antibiotic exposure and the development of childhood overweight and central adiposity. Int J Obes (Lond) 38:1290–1298CrossRef
  53.Cho I, Yamanishi S, Cox L et al (2012) Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488:621–626CrossRef PubMed PubMedCentral
  54.Cox LM, Yamanishi S, Sohn J et al (2014) Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell 158:705–721CrossRef PubMed PubMedCentral
  55.Nobel YR, Cox LM, Kirigin FF et al (2015) Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun 6:7486CrossRef PubMed PubMedCentral
  56.Ajslev TA, Andersen CS, Gamborg M, Sorensen TI, Jess T (2011) Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int J Obes (Lond) 35:522–529CrossRef
  57.Trasande L, Blustein J, Liu M, Corwin E, Cox LM, Blaser MJ (2013) Infant antibiotic exposures and early-life body mass. Int J Obes (Lond) 37:16–23CrossRef
  58.Maynard CL, Elson CO, Hatton RD, Weaver CT (2012) Reciprocal interactions of the intestinal microbiota and immune system. Nature 489:231–241CrossRef PubMed PubMedCentral
  59.DeSisto CL, Kim SY, Sharma AJ (2014) Prevalence estimates of gestational diabetes mellitus in the United States, Pregnancy Risk Assessment Monitoring System (PRAMS), 2007–2010. Prev Chronic Dis 11, E104CrossRef PubMed PubMedCentral
  60.Buckley BS, Harreiter J, Damm P et al (2012) Gestational diabetes mellitus in Europe: prevalence, current screening practice and barriers to screening. A review. Diabet Med 29:844–854CrossRef PubMed
  61.Larsen N, Vogensen FK, van den Berg FW et al (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5, e9085CrossRef PubMed PubMedCentral
  62.Fugmann M, Breier M, Rottenkolber M et al (2015) The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes. Sci Rep 5:13212CrossRef PubMed PubMedCentral
  63.Wright DP, Rosendale DI, Robertson AM (2000) Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin. FEMS Microbiol Lett 190:73–79CrossRef PubMed
  64.Fahrenkrog S, Harder T, Stolaczyk E et al (2004) Cross-fostering to diabetic rat dams affects early development of mediobasal hypothalamic nuclei regulating food intake, body weight, and metabolism. J Nutr 134:648–654PubMed
  65.Priyadarshini M, Thomas A, Reisetter AC et al (2014) Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns. Transl Res 164:153–157CrossRef PubMed PubMedCentral
  66.Park J, Kim M, Kang SG et al (2015) Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol 8:80–93CrossRef PubMed PubMedCentral
  67.Jumpertz R, Le DS, Turnbaugh PJ et al (2011) Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans. Am J Clin Nutr 94:58–65CrossRef PubMed PubMedCentral
  68.Chang PV, Hao L, Offermanns S, Medzhitov R (2014) The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A 111:2247–2252CrossRef PubMed PubMedCentral
  69.Schwiertz A, Taras D, Schäfer K et al (2010) Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 18:190–195CrossRef
  70.Bellahcene M, O’Dowd JF, Wargent ET et al (2013) Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. Br J Nutr 109:1755–1764CrossRef PubMed
  71.den Besten G, Bleeker A, Gerding A et al (2015) Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64:2398–2408CrossRef
  72.Li HP, Chen X, Li MQ (2013) Butyrate alleviates metabolic impairments and protects pancreatic beta cell function in pregnant mice with obesity. Int J Clin Exp Pathol 6:1574–1584PubMed PubMedCentral
  73.Ohira H, Fujioka Y, Katagiri C et al (2013) Butyrate attenuates inflammation and lipolysis generated by the interaction of adipocytes and macrophages. J Atheroscler Thromb 20:425–442CrossRef PubMed
  74.Macia L, Tan J, Vieira AT et al (2015) Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun 6:6734CrossRef PubMed
  75.Voltolini C, Battersby S, Etherington SL, Petraglia F, Norman JE, Jabbour HN (2012) A novel antiinflammatory role for the short-chain fatty acids in human labor. Endocrinology 153:395–403CrossRef PubMed
  76.Takahashi K (2014) Influence of bacteria on epigenetic gene control. Cell Mol Life Sci 71:1045–1054CrossRef PubMed
  77.Sealy L, Chalkley R (1978) The effect of sodium butyrate on histone modification. Cell 14:115–121CrossRef PubMed
  78.Furusawa Y, Obata Y, Fukuda S et al (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:446–450CrossRef PubMed
  79.Arpaia N, Campbell C, Fan X et al (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation. Nature 504:451–455CrossRef PubMed PubMedCentral
  80.Kellermayer R, Dowd SE, Harris RA et al (2011) Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice. FASEB J 25:1449–1460CrossRef PubMed PubMedCentral
  81.Kumar H, Lund R, Laiho A et al (2014) Gut microbiota as an epigenetic regulator: pilot study based on whole-genome methylation analysis. MBio 5, e02113PubMed PubMedCentral
  82.Hofmann AF, Hagey LR (2008) Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 65:2461–2483CrossRef PubMed
  83.Trabelsi MS, Daoudi M, Prawitt J et al (2015) Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells. Nat Commun 6:7629CrossRef PubMed PubMedCentral
  84.Selwyn FP, Csanaky IL, Zhang Y, Klaassen CD (2015) Importance of large intestine in regulating bile acids and glucagon-like peptide-1 in germ-free mice. Drug Metab Dispos 43:1544–1556CrossRef PubMed
  85.McMahan RH, Wang XX, Cheng LL et al (2013) Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem 288:11761–11770CrossRef PubMed PubMedCentral
  86.Wang YD, Chen WD, Yu D, Forman BM, Huang W (2011) The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice. Hepatology 54:1421–1432CrossRef PubMed PubMedCentral
  87.Gadaleta RM, van Erpecum KJ, Oldenburg B et al (2011) Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 60:463–472CrossRef PubMed
  88.Islam KB, Fukiya S, Hagio M et al (2011) Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 141:1773–1781CrossRef PubMed
  89.Everard A, Lazarevic V, Derrien M et al (2011) Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 60:2775–2786CrossRef PubMed PubMedCentral
  90.Lindsay KL, Brennan L, Kennelly MA et al (2015) Impact of probiotics in women with gestational diabetes mellitus on metabolic health: a randomized controlled trial. Am J Obstet Gynecol 212:496.e491-411
  91.Maurer AD, Eller LK, Hallam MC, Taylor K, Reimer RA (2010) Consumption of diets high in prebiotic fiber or protein during growth influences the response to a high fat and sucrose diet in adulthood in rats. Nutr Metab (Lond) 7:77CrossRef
  92.Rautava S, Collado MC, Salminen S, Isolauri E (2012) Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial. Neonatology 102:178–184CrossRef PubMed
  93.Luoto R, Laitinen K, Nermes M, Isolauri E (2010) Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr 103:1792–1799CrossRef PubMed
  94.Ilmonen J, Isolauri E, Poussa T, Laitinen K (2011) Impact of dietary counselling and probiotic intervention on maternal anthropometric measurements during and after pregnancy: a randomized placebo-controlled trial. Clin Nutr 30:156–164CrossRef PubMed
  95.Lindsay KL, Kennelly M, Culliton M et al (2014) Probiotics in obese pregnancy do not reduce maternal fasting glucose: a double-blind, placebo-controlled, randomized trial (Probiotics in Pregnancy Study). Am J Clin Nutr 99:1432–1439CrossRef PubMed
  96.Laitinen K, Poussa T, Isolauri E (2009) Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br J Nutr 101:1679–1687CrossRef PubMed
  97.Schultz M, Gottl C, Young RJ, Iwen P, Vanderhoof JA (2004) Administration of oral probiotic bacteria to pregnant women causes temporary infantile colonization. J Pediatr Gastroenterol Nutr 38:293–297CrossRef PubMed
  98.Gueimonde M, Sakata S, Kalliomäki M, Isolauri E, Benno Y, Salminen S (2006) Effect of maternal consumption of Lactobacillus GG on transfer and establishment of fecal bifidobacterial microbiota in neonates. J Pediatr Gastroenterol Nutr 42:166–170CrossRef PubMed
  99.Ismail IH, Oppedisano F, Joseph SJ, Boyle RJ, Robins-Browne RM, Tang ML (2012) Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiota. Pediatr Allergy Immunol 23:255–258CrossRef PubMed
  
• 作者单位：Taylor K. Soderborg (1)
  Sarah J. Borengasser (2)
  Linda A. Barbour (3) (4)
  Jacob E. Friedman (1) (3) (5)
  
  1. Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, Anschutz Medical Campus, Mail Stop 8106, 12801 East 17th Avenue, Aurora, CO, 80045, USA
  2. Department of Pediatrics, Section of Nutrition, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
  3. Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
  4. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
  5. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Maternal obesity and diabetes dramatically increase the long-term risk for obesity in the next generation, and pregnancy and lactation may be critical periods at which to aim primary prevention to break the obesity cycle. It is becoming increasingly clear that the gut microbiome in newborns and infants plays a significant role in gut health and therefore child development. Alteration of the early infant gut microbiome has been correlated with the development of childhood obesity and autoimmune conditions, including asthma, allergies and, more recently, type 1 diabetes. This is likely to be due to complex interactions between mode of delivery, antibiotic use, maternal diet, components of breastfeeding and a network of regulatory events involving both the innate and adaptive immune systems within the infant host. Each of these factors are critical for informing microbiome development and can affect immune signalling, toxin release and metabolic signals, including short-chain fatty acids and bile acids, that regulate appetite, metabolism and inflammation. In several randomised controlled trials, probiotics have been administered with the aim of targeting the microbiome during pregnancy to improve maternal and infant health but the findings have often been confounded by mode of delivery, antibiotic use, ethnicity, infant sex, maternal health and length of exposure. Understanding how nutritional exposure, including breast milk, affects the assembly and development of both maternal and infant microbial communities may help to identify targeted interventions during pregnancy and in infants born to mothers with obesity or diabetes to slow the transmission of obesity risk to the next generation. The aim of this review is to discuss influences on infant microbiota colonisation and the mechanism(s) underlying how alterations due to maternal obesity and diabetes may lead to increased risk of childhood obesity.