Toxicity and Pharmacokinetics of Sustained-Release Dexamethasone in Beagle Dogs

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• 作者：Arthur Driscoll ; Charles Blizzard
• 关键词：Canines ; Dexamethasone ; Drug concentration ; Drug delivery ; Intracanalicular depot ; Pharmacokinetics ; Punctum plug ; Sustained release ; Toxicity ; Toxicokinetics
• 刊名：Advances in Therapy
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：33
• 期：1
• 页码：58-67
• 全文大小：480 KB
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• 作者单位：Arthur Driscoll (1)
  Charles Blizzard (1)
  
  1. Ocular Therapeutix, 34 Crosby Drive, Bedford, MA, USA
  
• 刊物主题：Internal Medicine; Oncology; Cardiology; Rheumatology; Endocrinology; Pharmacology/Toxicology;
• 出版者：Springer Healthcare
• ISSN：1865-8652

文摘

Introduction The purpose of the present study was to examine the potential ocular and systemic toxicity and toxicokinetics/pharmacokinetics of sustained-release dexamethasone in canines.