GSTM1 Null Genotype and GSTP1 Ile105Val Polymorphism Are Associated with Alzheimer’s Disease: a Meta-Analysis

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• 作者：Mo Wang ; Yu Li ; Lulu Lin ; Guijun Song ; Teng Deng
• 关键词：Glutathione S ; transferases ; Alzheimer’s disease ; Meta ; analysis
• 刊名：Molecular Neurobiology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：53
• 期：2
• 页码：1355-1364
• 全文大小：318 KB
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• 作者单位：Mo Wang (1)
  Yu Li (1)
  Lulu Lin (1)
  Guijun Song (1)
  Teng Deng (2)
  
  1. Neurology Department No.1, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China
  2. Capital Medical University, Beijing, 100068, China
  
• 刊物主题：Neurosciences; Neurobiology; Cell Biology; Neurology;
• 出版者：Springer US
• ISSN：1559-1182

文摘

Published studies on the associations between glutathione S-transferase (GST) polymorphisms and Alzheimer’s disease reported controversial findings. A meta-analysis of published studies was performed to assess the associations between polymorphisms of GSTM1, GSTT1 and GSTP1, and Alzheimer’s disease. PubMed, Embase, and other databases were searched for case-control on the associations between polymorphisms of GSTM1, GSTT1 and GSTP1, and Alzheimer’s disease. The odds ratio (OR) and 95 % confidence interval (95 % CI) were used to assess the associations. Eleven articles were finally included into the meta-analysis, including eight studies on GSTM1 null genotype, six studies on GSTT1 null genotype, and six studies on GSTP1 Ile105Val polymorphism. Overall, GSTM1 null genotype was associated with increased risk of Alzheimer’s disease (fixed effect OR = 1.34, 95 % CI 1.10–1.64, P = 0.004). GSTT1 null genotype was not associated with risk of Alzheimer’s disease (random effect OR = 1.15, 95 % CI 0.68–1.92, P = 0.60). Besides, GSTP1 Ile105Val polymorphism was significantly associated with increased risk of Alzheimer’s disease (Val vs Ile: OR = 1.45, 95 % CI 1.05–1.99, P = 0.023; ValVal vs IleIle: OR = 1.87, 95 % CI 1.30–2.69, P = 0.001; ValVal vs IleIle + IleVal: OR = 1.76, 95 % CI 1.24–2.51, P = 0.002). No obvious risk of publication bias was observed in the meta-analysis. GSTM1 null genotype and GSTP1 Ile105Val polymorphism are associated with increased risk of Alzheimer’s disease. More studies with large sample size are needed to validate the findings in the meta-analysis. Keywords Glutathione S-transferases Alzheimer’s disease Meta-analysis