Meiotic behaviour of evolutionary sex-autosome translocations in Bovidae
详细信息 查看全文
- 作者：Miluse Vozdova ; Aurora Ruiz-Herrera ; Jonathan Fernandez…
- 刊名：Chromosome Research
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：24
- 期：3
- 页码：325-338
- 全文大小：1,373 KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Human Genetics
Animal Genetics and Genomics
Plant Genetics and Genomics - 出版者：Springer Netherlands
- ISSN：1573-6849
- 卷排序：24
文摘
The recurrent occurrence of sex-autosome translocations during mammalian evolution suggests common mechanisms enabling a precise control of meiotic synapsis, recombination and inactivation of sex chromosomes. We used immunofluorescence and FISH to study the meiotic behaviour of sex chromosomes in six species of Bovidae with evolutionary sex-autosome translocations (Tragelaphus strepsiceros, Taurotragus oryx, Tragelaphus imberbis, Tragelaphus spekii, Gazella leptoceros and Nanger dama ruficollis). The autosomal regions of fused sex chromosomes showed normal synapsis with their homologous counterparts. Synapsis in the pseudoautosomal region (PAR) leads to the formation of characteristic bivalent (in T. imberbis and T. spekii with X;BTA13/Y;BTA13), trivalent (in T. strepsiceros and T. oryx with X/Y;BTA13 and G. leptoceros with X;BTA5/Y) and quadrivalent (in N. dama ruficollis with X;BTA5/Y;BTA16) structures at pachynema. However, when compared with other mammals, the number of pachynema lacking MLH1 foci in the PAR was relatively high, especially in T. imberbis and T. spekii, species with both sex chromosomes involved in sex autosome translocations. Meiotic transcriptional inactivation of the sex-autosome translocations assessed by γH2AX staining was restricted to their gonosomal regions. Despite intraspecies differences, the evolutionary fixation of sex-autosome translocations among bovids appears to involve general mechanisms ensuring sex chromosome pairing, synapsis, recombination and inactivation.KeywordsBovidaeSex-autosome translocationX chromosomeY chromosomeMeiosisSynapsisRecombinationSex-chromosome inactivationHistone modification