Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
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- 作者：Leila Lujan-Barroso (1)
Carlos Alberto González (1)
Nadia Slimani (2)
Mireia Obón-Santacana (1)
Pietro Ferrari (2)
Heinz Freisling (2)
Kim Overvad (3)
Fran?oise Clavel-Chapelon (4) (5) (6)
Marie-Christine Boutron-Ruault (4) (5) (6)
Antoine Racine (4) (5) (6)
Verena Katzke (7)
Tilman Kühn (7)
Anne Tj?nneland (8)
Anja Olsen (8)
J. Ramón Quirós (9)
Emilio Sánchez-Cantalejo (10)
Pilar Amiano (11) (12) (13)
Carmen Navarro (13) (14) (15)
Aurelio Barricarte (16) (17)
Kay-Tee Khaw (18)
Nick Wareham (18)
Ruth C. Travis (19)
Antonia Trichopoulou (20) (21)
Christina Bamia (20) (21)
Vassiliki Benetou (20) (21)
Calogero Saieva (22)
Sara Grioni (23)
Rosario Tumino (24)
Paolo Vineis (25) (26)
Amalia Mattiello (27)
H. Bas Bueno-de-Mesquita (28) (29)
Peter D. Siersema (29)
Mattijs E. Numans (30) (31)
Petra H. Peeters (30) (32)
Ulrika Ericson (33)
Elisabet Wirf?lt (34)
Malin Sund (35)
Mattias Johansson (2) (36)
Elisabete Weiderpass (37) (38) (39) (40)
Guri Skeie (37)
Elio Riboli (25)
Heiner Boeing (41)
Eric J. Duell (1) - 关键词：Esophageal cancer ; Esophageal squamous cell carcinoma ; Esophageal adenocarcinoma ; Acrylamide intake ; Cohort ; Nutrition
- 刊名：Cancer Causes and Control
- 出版年：2014
- 出版时间：May 2014
- 年：2014
- 卷：25
- 期：5
- 页码：639-646
- 全文大小：186 KB
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22. Gonzalez CA, Pera G, Agudo A et al (2006) Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). Int J Cancer 118(10):2559-566 class="external" href="http://dx.doi.org/10.1002/ijc.21678" target="_blank" title="It opens in new window">CrossRef - 作者单位：Leila Lujan-Barroso (1)
Carlos Alberto González (1)
Nadia Slimani (2)
Mireia Obón-Santacana (1)
Pietro Ferrari (2)
Heinz Freisling (2)
Kim Overvad (3)
Fran?oise Clavel-Chapelon (4) (5) (6)
Marie-Christine Boutron-Ruault (4) (5) (6)
Antoine Racine (4) (5) (6)
Verena Katzke (7)
Tilman Kühn (7)
Anne Tj?nneland (8)
Anja Olsen (8)
J. Ramón Quirós (9)
Emilio Sánchez-Cantalejo (10)
Pilar Amiano (11) (12) (13)
Carmen Navarro (13) (14) (15)
Aurelio Barricarte (16) (17)
Kay-Tee Khaw (18)
Nick Wareham (18)
Ruth C. Travis (19)
Antonia Trichopoulou (20) (21)
Christina Bamia (20) (21)
Vassiliki Benetou (20) (21)
Calogero Saieva (22)
Sara Grioni (23)
Rosario Tumino (24)
Paolo Vineis (25) (26)
Amalia Mattiello (27)
H. Bas Bueno-de-Mesquita (28) (29)
Peter D. Siersema (29)
Mattijs E. Numans (30) (31)
Petra H. Peeters (30) (32)
Ulrika Ericson (33)
Elisabet Wirf?lt (34)
Malin Sund (35)
Mattias Johansson (2) (36)
Elisabete Weiderpass (37) (38) (39) (40)
Guri Skeie (37)
Elio Riboli (25)
Heiner Boeing (41)
Eric J. Duell (1)
1. Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Avda Gran Via 199-203, 08908, L’Hospitalet de Llobregat, Barcelona, Spain
2. International Agency for Research on Cancer (IARC-WHO), Lyon, France
3. Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
4. Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women’s Health team, Villejuif, France, INSERM, Villejuif, France
5. Univesity Paris Sud, UMRS 1018, Villejuif, France
6. IGR, Villejuif, France
7. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
8. Danish Cancer Society Research Center, Copenhagen, Denmark
9. Public Health Directorate, Asturias, Spain
10. Andalusian School of Public Health, CIBER Epidemiología y Salud Pública (CIBERESP), Granada, Spain
11. Public Health Division of Gipuzkoa, San Sebastián, Spain
12. Health Department of Basque Region, BioDonostia Research Institute, San Sebastián, Spain
13. CIBER Epidemiologia y Salud Pública (CIBERESP), Madrid, Spain
14. Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain
15. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
16. Navarre Public Health Institute, Pamplona, Spain
17. Consortium for Biomedical Research in Epidemiology and Public Health, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
18. MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
19. Cancer Epidemiology Unit, University of Oxford, Oxford, UK
20. Hellenic Health Foundation, Athens, Greece
21. WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
22. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Italy
23. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
24. Cancer Registry and Histopathology Unit, “Civic - M.P.Arezzo-Hospital, ASP Ragusa, Ragusa, Italy
25. School of Public Health, Imperial College London, London, UK
26. HuGeF Foundation, Turin, Italy
27. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
28. National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
29. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands
30. Department of Primary Care Julius Center, UMC, Utrecht, The Netherlands
31. Department of General Practice and Elderly Care, VUmc Amsterdam, Amsterdam, The Netherlands
32. Department of Epidemiology and Biostatistics, Imperial College London, London, UK
33. Diabetes and Cardiovascular Disease, Genetic Epidemiology, Department of Clinical Sciences, Lund University, Malm?, Sweden
34. Department of Clinical Sciences, Lund University, Malm?, Sweden
35. Department of Surgery, Ume? University, Ume?, Sweden
36. Department of Biobank Research, Ume? University, Ume?, Sweden
37. Department of Community Medicine, Faculty of Health Sciences, University of Troms?, Troms?, Norway
38. Department of Research, Cancer Registry of Norway, Oslo, Norway
39. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
40. Samfundet Folkh?lsan, Helsinki, Finland
41. Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany - ISSN：1573-7225
文摘
Purpose The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Multivariate Cox proportional hazards models were used to estimate the HR and 95?% confidence interval (95?% CI). Since nonlinear relations were observed, HRs were displayed for quartiles of acrylamide intake in μg per day. Results After a mean follow-up of 11?years, 341 EC were identified, 142 of which were EAC, 176 ESCC, and 23 other histological types or not specified. An increase in EC risk was observed in the second and third quartiles (HRQ2vsQ1 1.75, 95?% CI 1.12-.74; HRQ3vsQ1 1.66, 95?% CI 1.05-.61), but not in the fourth quartile, and there was no evidence for a linear dose–response trend. HRs were similarly elevated but not statistically significant when ESCC and EAC were analyzed separately, due to the small number of cases observed. No associations were observed when quartiles were based on energy-adjusted acrylamide intake. Conclusions In the EPIC cohort, an association between estimated dietary acrylamide intake and an increased risk of developing EC was observed in the middle quartiles but not in the highest quartile; however, results from other larger cohorts or consortia, and results from biomarker studies, might add to the evidence provided by this analysis, suggesting that acrylamide is not an important risk factor for EC.