Genotypes of the vitamin D-binding protein gene in patients with chronic obstructive pulmonary disease and in the healthy population of the Republic Bashkortostan

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• 作者：G. F. Korytina ; L. Z. Akhmadishina ; D. G. Yanbaeva and T. V. Victorova
• 关键词：chronic obstructive pulmonary disease ; vitamin D ; binding protein ; haplotype ; association
• 刊名：Molecular Biology
• 出版年：2006
• 出版时间：March 2006
• 年：2006
• 卷：40
• 期：2
• 页码：200-206
• 全文大小：166 KB

文摘

Allele and genotype frequency distributions of the vitamin D-binding protein gene (DBP) were studied in patients with chronic obstructive pulmonary disease (COPD, N = 298) and healthy individuals (N = 237) from two ethnic groups (Tatars and Russians) resident in the Republic Bashkortostan. The DBP genotype frequency distribution significantly differed between Tatars and Russians (X 2 = 8.854, df = 5, P = 0.04). The DBP allele frequency distribution was similar in healthy subjects of both ethnic groups, with allele frequency decreasing as GC*1S > GC*1F > GC*2. The most common DBP genotype was GC*1F/1S in Tatars (36.79 % ) and GC*1S/2 in Russians (34.62 % ). It was demonstrated that, in Tatars, the genotype GC*1F/1S is protective against COPD, its frequency being significantly lower in COPD patients than in healthy subjects (19.85 % vs. 36.79 % ; X 2 = 7.622, P = 0.0067, P <sub>corsub> = 0.0335; OR = 0.42, 95 % CI 0.42–0.95). On the other hand, the genotype GC*1F/2 was more common among COPD patients than among healthy individuals (19.08 % vs. 8.49 % ; X 2 = 4.52, P = 0.033, P <sub>corsub> = 0.165; OR = 2.54, 95 % CI 1.067–6.20). No differences in DBP genotype and allele frequency distributions was found between COPD patients and healthy individuals in the Russian population.