Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients

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• 作者：Rong Biaoxue (1)
  Jiang Xiling (2)
  Yang Shuanying (1)
  Zhang Wei (1)
  Cai Xiguang (3)
  Wang Jinsui (4)
  Zhang Min (4)
  
• 关键词：Lung cancer ; Hsp90 ; beta ; Annexin A1 ; Survival ; Lymphatic metastasis ; Biomarker
• 刊名：Journal of Experimental & Clinical Cancer Research
• 出版年：2012
• 出版时间：December 2012
• 年：2012
• 卷：31
• 期：1
• 全文大小：1240KB
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• 作者单位：Rong Biaoxue (1)
  Jiang Xiling (2)
  Yang Shuanying (1)
  Zhang Wei (1)
  Cai Xiguang (3)
  Wang Jinsui (4)
  Zhang Min (4)
  
  1. Department of Respiratory Medicine, Second Affiliated Hospital, Xi’an Jiaotong University, 157, Xi 5 Road, Xi’an, 710004, People’s Republic of China
  2. Department of Oncology, Weinan Central Hospital, Weinan, China
  3. Department of Respiratory Medicine, People’s Hospital of Gansu Province, Lanzhou, China
  4. Department of Pathology, People’s Hospital of Gansu Province, Lanzhou, China
  
• ISSN：1756-9966

文摘

Background Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed. Methods The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot. Results Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p-lt;-.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p-lt;-.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p-lt;-.05). Conclusion The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.