Genetic polymorphisms of interleukin-1 beta and osteosarcoma risk

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• 作者：Yu He (1)
  XinJun Liang (2)
  ChunQing Meng (1)
  ZengWu Shao (1)
  Yong Gao (1)
  Qiang Wu (1)
  JianXiang Liu (1)
  Hong Wang (1)
  ShuHua Yang (1)
  
• 关键词：Osteosarcoma ; Interleukin ; 1 beta ; Gene polymorphism ; Hospital ; based case–control study
• 刊名：International Orthopaedics
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：38
• 期：8
• 页码：1671-1676
• 全文大小：145 KB
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• 作者单位：Yu He (1)
  XinJun Liang (2)
  ChunQing Meng (1)
  ZengWu Shao (1)
  Yong Gao (1)
  Qiang Wu (1)
  JianXiang Liu (1)
  Hong Wang (1)
  ShuHua Yang (1)
  
  1. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, 430022, Hubei Province, China
  2. Department of Medical Oncology, Cancer Hospital of Wuhan University and Hubei Cancer Hospital, Wuhan, 430079, China
  
• ISSN：1432-5195

文摘

Purpose Osteosarcoma is the most common childhood bone cancer. Interleukin-1 beta (IL-1B) is crucially involved in osteosarcoma carcinogenesis. Whether genetic polymorphisms of IL-1B also influence osteosarcoma risk is unknown. The aim of this study was to investigate the association between IL-1B gene polymorphisms and osteosarcoma risk in Chinese Han patients. Methods A hospital-based case–control study involving 120 osteosarcoma patients and 120 controls was conducted. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect three IL-1B gene polymorphisms (?1?T/C, ?11 C/T and +3954 C/T) in these patients. Results Patients with osteosarcoma had a significantly lower frequency of ?1?CC genotype [odds ratio (OR) = 0.40, 95?% confidence interval (CI)--.17-.92; P--.03] and ?1 C allele (OR--.67, 95?% CI--.46-.99; P--.04) than controls. Patients with osteosarcoma had a significantly lower frequency of ?11 TT genotype (OR--.40, 95?% CI--.17-.95; P--.04) than controls. The +3954 C/T gene polymorphisms were not associated with a risk of osteosarcoma. When stratified by Enneking stage, tumour location, histological type, tumour metastasis of osteosarcoma and family history of cancer, no statistically significant results were found. Conclusions This is the first study to provide evidence for an association of IL-1B gene polymorphisms with osteosarcoma risk.