Characterization of single-domain antibodies against Foot and Mouth Disease Virus (FMDV) serotype O from a camelid and imaging of FMDV in baby hamster kidney-21 cells with single-domain antibody-quantum dots probes
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- 作者：Di Wang ; Shunli Yang ; Shuanghui Yin ; Youjun Shang ; Ping Du…
- 关键词：Foot ; and ; mouth disease virus serotype O ; Immune library ; Single domain antibody ; Quantum dots ; Probe ; Imaging
- 刊名：BMC Veterinary Research
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：11
- 期：1
- 全文大小：3,481 KB
- 刊物主题：Veterinary Medicine; Zoology; Transgenics;
- 出版者：BioMed Central
- ISSN：1746-6148
文摘
Background Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoofed animals and causes significant economic losses to husbandry worldwide. The variable domain of heavy-chain antibodies (VHHs or single domain antibodies, sdAbs) are single-domain antigen-binding fragments derived from camelid heavy-chain antibodies.