Elevated expression patterns and tight correlation of the PLCE1 and NF- signaling in Kazakh patients with esophageal carcinoma

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• 作者：Xiao-bin Cui (1) (2) (3)
  Xue-lian Pang (1)
  Su Li (1)
  Jing Jin (1)
  Jian-ming Hu (1)
  Lan Yang (1)
  Chun-xia Liu (1)
  Li Li (3)
  Shu Jun Wen (4)
  Wei-hua Liang (1)
  Yun-zhao Chen (1) (2) (3)
  Feng Li (1) (2) (3)
  
• 关键词：Esophageal squamous cell carcinoma ; Kazakh ; PLCE1 ; NF
• 刊名：Medical Oncology
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：31
• 期：1
• 全文大小：
• 作者单位：Xiao-bin Cui (1) (2) (3)
  Xue-lian Pang (1)
  Su Li (1)
  Jing Jin (1)
  Jian-ming Hu (1)
  Lan Yang (1)
  Chun-xia Liu (1)
  Li Li (3)
  Shu Jun Wen (4)
  Wei-hua Liang (1)
  Yun-zhao Chen (1) (2) (3)
  Feng Li (1) (2) (3)
  
  1. Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, North 4th Road, Shihezi, 832002, Xinjiang, People Republic of China
  2. Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People Republic of China
  3. Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, People Republic of China
  4. Operating Room, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, People Republic of China
  
• ISSN：1559-131X

文摘

This study investigated the expression of the phospholipase C epsilon 1 (PLCE1) and nuclear factor-kappaB (NF-)-related proteins in Kazakh patients with esophageal squamous cell carcinoma (ESCC). Tissue microarrays of 90 ethnic Kazakh patients with ESCC and exhibiting clinical characteristics were analyzed for protein expression of PLCE1, IKK IKB p50, and p65 by immunohistochemistry. Correlations between histoscores of PLCE1 and NF--related proteins were determined using Spearman rank correlation tests. Expression of PLCE1 and NF--related proteins significantly increased in tumor tissues compared with normal esophageal tissues (P=9.48107, 1.24105, 0.004, 0.003, and 2.83105, respectively). Upregulation of PLCE1 was significantly correlated with advanced tumor-node-metastasis stages (P=0.018) and lymph node metastasis (P=0.003). Overexpression of IKKand IKBwas associated with ESCC stages I/II (P=3.36104 and 0.022, respectively). Increased expression of p50 was significantly higher in patients with lymph node metastasis than without lymph node metastasis (P=0.048). Elevated expression of p65 protein was significantly correlated with poor and moderately differentiated ESCC and depth of tumor invasion (P=0.026 and 0.010, respectively). Significant positive correlations were observed between the expression of PLCE1 and NF--related proteins, especially IKK(r=0.246 and P=0.025) and p50 (r=0.244 and P=0.024). These results suggest, for the first time, that upregulation of PLCE1 is correlated with increased expression of NF--related proteins in Kazakh patients with ESCC, suggesting that interaction between PLCE1 with the NF- signal pathway may be responsible for the carcinogenesis of ESCC, such as ESCC-related inflammation.