Dysphonia as a sign of HPV laryngeal infection: a case report

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• 作者：Carlos Eduardo Gama Longubuco (45)
  Helena Lucia Barroso dos Reis (46)
  Fernanda Sampaio Cavalcante (47)
  Carla Renata Petillo de Pinho (48)
  Nathalia Silva Oliveira (49)
  Alcina Frederica Nicol (49)
  Renata Quintella Zamolyi (50)
  Dennis de Carvalho Ferreira (47) (48) (51) (52)
  
  45. Biologic Science Undergraduate Program - Microbiology Program ; Salgado de Oliveira University ; Rio de Janeiro ; Brazil
  46. Ginecology and Obstetrics Outpatient Care ; Federal University of Esp铆rito Santo (UFES) ; Vit贸ria ; Brazil
  47. Paulo de Goes Microbiology Institute - Medical Microbiology Department ; Federal University of Rio de Janeiro ; Rio de Janeiro ; Brazil
  48. Oral Medicine Area ; School of Dentistry ; Veiga de Almeida University ; Rio de Janeiro ; Brazil
  49. Laboratory of Interdisciplinary Medical Research (LIPMED) ; Oswaldo Cruz Foundation -Fiocruz ; Rio de Janeiro ; Brazil
  50. Pathology Anatomy Service ; Bonsucesso Federal Hospital ; Rio de Janeiro ; Brazil
  51. CAPES Fellow (Bolsista da CAPES) ; Proc. n BEX 9203 ; CAPES Foundation ; Ministry of Education of Brazil ; Brasilia ; Brazil
  52. Abeu University Center ; Belford Roxo ; Rio de Janeiro ; Brazil
  
• 关键词：Dysphonia ; Human papillomavirus ; Vocal fold
• 刊名：BMC Research Notes
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：7
• 期：1
• 全文大小：936 KB
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• 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1756-0500

文摘

Background Voice dysfunction or dysphonia may be associated with several clinical conditions. Among these, laryngeal human papillomavirus (HPV)-induced lesions should be considered as a possible causative factor. We report a case of dysphonia in a patient presenting with an HPV laryngeal lesion. We also discuss the clinical features of the disease, its histopathological findings, and treatment and rigorous follow-up. Case presentation We report a case of laryngeal papilloma in a 29-year-old, Afro-descendant, male patient with dysphonia. He was a non-smoker and was not a drug user. Videolaryngostroboscopy revealed signs suggestive of pharyngolaryngeal reflux. The right vocal fold presented with a papillomatous aspect in the posterior third, which underwent excision. Histopathological examination showed a nodular lesion of the right vocal fold, conclusive of squamous papilloma with absence of malignancy. Conclusion Patients presenting with persistent voice dysfunction or dysphonia should be investigated for possible laryngeal HPV infection. Diagnostic confirmation by HPV genotyping is important for follow-up of potential recurrence.