Serum levels of soluble secreted α-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis

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• 作者：Yoshiko Shimamura (1)
  Kazu Hamada (1)
  Kosuke Inoue (1)
  Koji Ogata (1)
  Masayuki Ishihara (1)
  Toru Kagawa (1)
  Mari Inoue (1)
  Shimpei Fujimoto (1)
  Mika Ikebe (3)
  Kenji Yuasa (3)
  Shigeo Yamanaka (2)
  Teturo Sugiura (2)
  Yoshio Terada (1) terada@kochi-u.ac.jp
• 关键词：α ; Klotho – CKD – CKD–MBD – FGF23
• 刊名：Clinical and Experimental Nephrology
• 出版年：2012
• 出版时间：October 2012
• 年：2012
• 卷：16
• 期：5
• 页码：722-729
• 全文大小：461.8 KB
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• 作者单位：1. Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohashu, Oko-cho, Nankoku, 783-8505 Japan2. Laboratory Medicine, Kochi Medical School, Kochi University, Kohashu, Oko-cho, Nankoku, 783-8505 Japan3. Kochi-Takasu Hospital, Kochi, Japan
• ISSN：1437-7799

文摘

Background α-Klotho was first identified as an aging gene and was later shown to be a regulator of phosphate metabolism. Fibroblast growth factor 23 (FGF23) is the key regulator of phosphate metabolism. Serum levels of soluble α-Klotho in chronic kidney disease (CKD) patients have not previously been determined, especially in relation with FGF23 and creatinine levels. This study was designed to investigate whether serum soluble α-Klotho levels are modulated by renal function, age, and FGF23 level in CKD patients. This study is the first report on the utility of measuring soluble α-Klotho levels in human CKD.